of the Clinical Problem Approximately150000adultspresenteachyearwithanunprovoked first seizure in theUnited States, although less thanhalf have a readilyapparentcause.1 It is important todistinguishseizures fromevents that canmimic epilepsy, such as syncope,movement disorders, and toxic-metabolicencephalopathy,andrecongizethat transient factors that temporarily lowerseizurethreshold inanotherwi...

BACKGROUND We aimed to determine the risk of recurrence for symptomatic venous thromboembolism (VTE) provoked by different transient risk factors. DATA SOURCES MEDLINE, EMBASE, and Cochrane Collaboration Registry of Randomized Trials databases were searched. STUDY SELECTION Prospective cohort studies and randomized trials of patients with a first episode of symptomatic VTE provoked by a tra...

PURPOSE To evaluate the value of 24-hour video-EEG (VEEG) in assessing recurrence risk after a first unprovoked seizure. METHOD Consecutively 134 patients with a first unprovoked epileptic seizure were recuited from West China Hospital, Sichuan University, between January 2010 and January 2013. All patients underwent VEEG and magnetic resonance imaging (MRI) of the brain, Each patient had at ...

The decision to treat a child with a drug depends upon the individual (frequency of seizures, epilepsy syndrome and neurological findings) and also the wishes of the parents/carers. It remains unclear when drug treatment should beginl-3, and numerous attempts have been made to accurately predict the risk of epilepsy developing (i.e. recurrent, spontaneous seizures) after the first unprovoked se...

The risk of recurrence after a first unprovoked seizure has been examined in numerous observational studies and two large, high-quality randomized trials. Overall, in untreated individuals, 40-50% can expect a recurrence within 2 years of the initial seizure. Treatment may reduce this risk by as much as half. Those at the greatest risk of recurrence have either an abnormal EEG or an identifiabl...

An 11-year-old boy presented to us with intellectual disability and recurrent, unprovoked seizures since 3–4 months of age. His history revealed that the initial were generalised-onset tonic type. MRI brain at time showed benign enlargement subarachnoid spaces ([