PURPOSE We describe the diagnosis and treatment of urethral strictures in women. MATERIALS AND METHODS We retrospectively identified female urethral strictures from 1998 to 2010. Study inclusion criteria were 1) clinical diagnosis of stricture, 2) stricture seen on cystoscopy, 3) urethral obstruction on videourodynamics according to the Blaivas-Groutz nomogram and/or 4) urethral caliber less ...

Anterior urethral valves (AUVs) is an unusual cause of congenital obstruction of the male urethra, being 15-30 times less common than posterior urethral valves. We present a case of AUV diagnosed at 24th gestational week. Ultrasonography and fetal MRI revealed hydronephrotic kidneys with ureteral duplicity, a distended bladder and perineal cystic mass which confirmed dilated anterior urethra in...

Urethral amyloidosis is a rare condition that can cause hematuria and urinary obstruction symptoms. While there is no established association between immunoglobulin A (IgA) nephropathy and secondary amyloidosis, which is typically found in chronic inflammatory conditions, it is hypothesized that IgA nephropathy may be a systemic condition with inflammatory mediators. We present a case of urethr...

background: the treatment of urethral stricture in female patients is through dilatation of the urethra by tubes of increasing diameter. there are two main methods: intermittent dilatation and on demand dilatation. objectives: the main aim of this study was to compare the results of these two methods, and to determine the best one. patients and methods: in this clinical trial study, we reviewed...

OBJECTIVE To analyze the lower urinary tract symptoms (LUTS) and video-urodynamic characteristics of women with clinically unsuspected bladder outlet obstruction (BOO). METHODS From 1997 to 2010, a total of 1605 women with bothersome LUTS received video-urodynamic study in our unit. We reviewed the charts of 212 women diagnosed with BOO based on video-urodynamic criteria and 264 women without...

Chronic urethral obstruction and the ensuing bladder wall remodeling can lead to diminished bladder smooth muscle (BSM) contractility and debilitating lower urinary tract symptoms. No effective pharmacotherapy exists to restore BSM contractile function. Neuropilin 2 (Nrp2) is a transmembrane protein that is highly expressed in BSM. Nrp2 deletion in mice leads to increased BSM contraction. We de...