Homocysteic acid (HA) has been suggested as a pathogen in a mouse model of Alzheimer's disease (AD), 3xTg-AD. However, it is not established whether HA is involved in humans. We investigated the relationship between urinary HA levels and Mini-Mental State Examination (MMSE) scores in AD patients (n = 70) and non-AD controls (n = 34). We found a positive, statistically significant relationship b...

Background: Normal vaginal delivery causes sexual dysfunction as well as urinary and fecal incontinence, which can threaten a person's quality of life. It is believed that pelvic floor muscle strength is the most important factor in improving sexual satisfaction and function and urinary control. Therefore, This study aimed to investigate the role of physiotherapy and pelvic floor exercises in r...

OBJECTIVE To assess renal involvement in sick neonates referred to Neonatal Intensive Care Unit (NICU) using standard renal parameters and urinary beta 2 microglobulin (B2M) excretion. DESIGN Descriptive study. SETTING Level II NICU and Nephrology Division of Pediatric Tertiary hospital. SUBJECTS Forty six term sick neonates transferred for neonatal care and forty healthy term neonates wh...

Titin is a giant protein that functions as molecular spring in sarcomeres. interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. breaks down to form urinary titin N-fragments, which are measurable urine. Urinary N-fragment was originally reported be useful biomarker diagnosis muscle dystrophy. Recently, has been increasingly gaining attention no...

BACKGROUND Adenosine-5'-triphosphate (ATP) is a neurotransmitter and inflammatory cytokine implicated in the pathophysiology of lower urinary tract disease. ATP additionally reflects microbial biomass thus has potential as a surrogate marker of urinary tract infection (UTI). The optimum clinical sampling method for ATP urinalysis has not been established. We tested the potential of urinary ATP ...

Oxidative DNA damage may play an important role in the human carcinogenic process. Recently, we reported a case of bladder cancer among 4, 4'-methylenebis (2-chloroaniline) (MBOCA)-exposed workers. By measuring the plasma level of 8-hydroxydeoxyguanosine (8-OHdG), we investigated the association between oxidative DNA damage and MBOCA exposure. In addition, we examined the effects of different c...

OBJECTIVE Although both orthostatic hypotension and urinary incontinence have been reported in a number of parkinsonian syndromes, such as Parkinson's disease (PD), multiple system atrophy (MSA), dementia with Lewy bodies (DLB), corticobasal degeneration (CBD), and progressive supranuclear palsy (PSP), differences in the evolution of these features have not been studied systematically in pathol...

conclusions urinary ghrelin concentration was lower before treatment of uti and significantly increased after cessation of inflammation. further studies are required for more definite results. patients and methods this study was performed on 40 hospitalized children with uti at mofid children’s hospital during years 2013 to 2014. ghrelin and creatinine were measured before and after treatment. ...