We correlated the changes in glucose-induced insulin secretion with those observed in glucose metabolism and hexokinase/glucokinase activity in islets from normal sucrose-fed hamsters. Blood glucose and insulin levels were measured in normal male hamsters fed with (S5) or without (C5) 10% sucrose in the drinking water for 5 weeks. Isolated islets (collagenase digestion) from both groups of anim...

The present study examined if high intensity training (HIT) could increase the expression of oxidative enzymes in fast-twitch muscle fibers causing a faster oxygen uptake (V˙O2) response during intense (INT), but not moderate (MOD), exercise and reduce the V˙O2 slow component and muscle metabolic perturbation during INT. Pulmonary V˙O2 kinetics was determined in eight trained male cyclists (V˙O...

The max-coloring problem is to compute a legal coloring of the vertices of a graph G = (V,E) with vertex weights w such that ∑k i=1 maxv∈Ci w(vi) is minimized, where C1, . . . , Ck are the various color classes. For general graphs, max-coloring is as hard as the classical vertex coloring problem, a special case of the former where vertices have unit weight. In fact, in some cases it can even be...

Apparently homogeneous tyrosine phenol-lyase (TPL) from Erwinia herbicola has been prepared by a new method. The pH-dependencies of the main kinetic parameters for the reactions of Erwinia TPL with tyrosine, 2-fluorotyrosine, 3-fluorotyrosine, 2-chlorotyrosine, and 3,4-dihydroxyphenylalanine (DOPA) have been studied. The pattern of pH-dependence of V(max) depends on the nature of the substituen...

Cytochrome P450 (P450)-dependent metabolism of all-trans-retinoic acid (atRA) is important for the expression of its biological activity. Because the human P450s involved in the formation of the principal atRA metabolites have been only partially identified, the purpose of this study was to identify the human P450s involved in atRA metabolism. The use of phenotyped human liver microsomes (n = 1...

Reinforcement Learning (RL) is a heuristic method for learning locally optimal policies in Markov Decision Processes (MDP). Its classical formulation (Sutton & Barto 1998) maintains point estimates of the expected values of states or state-action pairs. Bayesian RL (Dearden, Friedman, & Russell 1998) extends this to beliefs over values. However the concept of values sits uneasily with the origi...

Unless the widely believed P 6= NP conjecture is false, there is no polynomial algorithm that can solve all instances of an NP-hard problem. Thus, when faced with an NP-hard problem (such as the Max-Cut problem discussed below) one has three options: to use an exponential type algorithm that solves exactly the problem in all instances, to design polynomial time algorithms that only work for som...

Increased airway responsiveness (AR) is one of the main pathophysiological manifestations of asthma. The present study aimed to define the clinical features associated with increased AR in infants with recurrent lower respiratory tract symptoms. AR was evaluated by performing a novel dosimetric methacholine challenge test. Increased AR to methacholine, defined as a methacholine dose of < or =0....