OBJECTIVE To investigate the retrograde changes in the dorsal motor nuclei (DMV) of the vagus nerve after vagotomy in rats. METHODS Nissl staining and immunohistochemistry were used to observe the morphological and quantitative changes of the DMV and alterations of the expression of iNOS and NADPH after severing of the vagus nerve in adult male Wistar rats. RESULTS Compared with the control...

Obese hyperglycemic mice have large pancreatic islets and high levels of serum insulin and blood glucose. Vagotomy was performed on 3-wk-old animals to investigate the role of gut cholinergic innervation in young Umea ob/ob mice. After vagotomy, obesity and hyperglycemia are dissociated. Weight increase in obese vagotomized mice was lower than in sham-operated controls during the 1st wk postope...

Gastric adaptation was impaired immediately after the performance of complete vagotomy in a series of 20 acute experiments in the dog. Preliminary isolation of the intact vagi in 10 of these animals produced alterations in adaptation similar to those seen after vagal division. It is concluded that alterations in gastric adaptation are not a reliable intraoperative aid to complete vagotomy. Thes...

bezoar, an illness known for a long time is nowadays the subject of renewed interest. this is due to the fact that it may occur as a complication of the gastric operations now used with increasing frequency. a case of phytobezoar after vagotomy and pyloroplasty for peptic ulcer is reported. the patient recovered with normal medical treatment. codifying the etiology, pathogeny and treatment has ...

Dragstedt believed that basal hypersecretion of gastric acid was the root cause of duodenal ulcer, that the hypersecretion was due to an increased vagal stimulation, and that vagotomy would therefore cure duodenal ulcer. He introduced vagotomy and demonstrated that the operation was successful in curing most patients of their duodenal ulcers. This article reviews how further research in the suc...

Completeness of vagotomy has been assessed by use of the electrical stimulation test and the insulin test in 50 patients suffering from chronic duodenal ulceration. A positive result from either was taken as evidence of incomplete vagotomy. The electrical stimulation test provided such evidence more often than the insulin test.No early positive insulin test result was encountered in any vagotom...

The microscopic study of the morphological changes in the rabbit pancreas were investigated after vagotomy. Structural changes were observed in the pancreatic acinar cells and in the islets of langerhans two and three weeks after vagotomy. Measurement of the fasting blood glucose level at different intervals of time post operatively and also the glucose tolerance test confirmed the structural c...