Most cancer-associated genetic variants identified from genome-wide association studies (GWAS) do not obviously change protein structure, leading to the hypothesis that the associations are attributable to regulatory polymorphisms. Translating genetic associations into mechanistic insights can be facilitated by knowledge of the causal regulatory variant (or variants) responsible for the statist...

Although the causes of Parkinson's disease (PD) are thought to be primarily environmental, recent studies suggest that a number of genes influence susceptibility. Using targeted case recruitment and online survey instruments, we conducted the largest case-control genome-wide association study (GWAS) of PD based on a single collection of individuals to date (3,426 cases and 29,624 controls). We ...

Monte Carlo simulation (MCS) of antimicrobial dosage regimens during drug development to derive predicted target attainment values is frequently used to choose the optimal dose for the treatment of patients in phase 2 and 3 studies. A criticism is that pharmacokinetic (PK) parameter estimates and variability in healthy volunteers are smaller than those in patients. In this study, the initial es...

BACKGROUND Compared with the traditional oral administration form, injection administration is basically superior in terms of both biological availability and therapeutic effects. However, few researches have focused on the traditional Chinese medicinal injection due to the complicated constituents and the intricate mechanism of action. METHODS In the present work, a novel systems pharmacolog...

There is a strong body of circumstantial evidence which implicates genetics in the aetiology and pathology of varicose veins and venous ulcer disease. The aim of this review is to consider the current knowledge of the genetic associations and the ways in which new genetic technologies may be applied to advancing our understanding of the cause and progression of these venous diseases. A number o...

Considering the importance of validation of customers in the cross-dock and since this is one of the problems of implementing cross-dock system in Iran, this study attempted to extract customer validation criteria. The purpose of the research is to eliminate the distrust of distributors in receiving the funds of the sent items and the statistical sample of this research is the experts of the sy...

in this study, application ofweap model (soil moisture method) have been investigated for simulating hydrological behavior in ahar-chai basin. according to the development of pressurized irrigation systems in this basin, since 2005, two models were carried out for two periods, pre-pressurized period (1998-2006) and pressurized period (2006-2013). irrigation method in first model was surface irr...

the method has been developed and validated for the determination of hydroquinone in liposomal formulation. the samples were dissolved in methanol and evaluated in 293 nm. the validation parameters such as linearity, accuracy, precision, specificity, limit of detection (lod) and limit of quantitation (loq) were determined. the calibration curve was linear in 1-50 µg /ml range of hydroquinone an...

soil moisture retention curve is one of the soil hydraulic prosperities which its direct measurement is time consuming and expensive. therefore, indirect methods such as developing pedotransfer functions have been used to predict this characteristic from soil readily available or easily measurable data. in this study, multiple linear regression method was used to develop point pedotransfer func...