BACKGROUND This study was designed to evaluate the incidence and mechanisms of mitral regurgitation following mitral balloon valvotomy (MBV) in 40 consecutive patients with symptomatic tight pliable mitral stenosis. METHODS AND RESULTS Transthoracic echocardiography with color flow mapping was performed before and 24 hours after the procedure. Patients who developed significant mitral regurgi...

BACKGROUND Fibro-elastic deficiency (FED) and diffuse myxomatous degeneration (DMD) are phenotypes of degenerative mitral valve disease defined morphologically. Whether physiological differences in annular and valvular dynamics exist between these phenotypes remains unknown. METHODS AND RESULTS We performed triple quantitation of cardiac remodeling and of mitral regurgitation severity and of ...

DMBlackstone EH. Tricuspid valve repair: durability and risk factors for failure. J Thorac Cardiovasc Surg 2004;127:674–85. [13] Chumnanvej S, Wood MJ, MacGillivray TE, Vidal Melo MF. Effect of tricuspid annuloplasty on postoperative tricuspid regurgitation following left ventricular assist device implantation. Anesth Analg 2006; 102:SCA54. [14] Scalia GM, McCarthy PM, Savage RM, Smedira NG, Th...

OBJECTIVES REGULATE trial was designed to compare the efficacy and safety of benfluorex versus pioglitazone in type 2 diabetes mellitus (DM) patients. METHODS Double-blind, parallel-group, international, randomised, non-inferiority trial. More than half of the 196 participating centres were primary care centres. Patients eligible had type 2 DM uncontrolled on sulfonylurea. 846 were randomised...

Background The quantification of valvular regurgitation by CMR is usually a second-line diagnostic tool that is used when echocardiography has proven inconclusive. According to guidelines are aortic and mitral regurgitations considered severe if the regurgitation volume > 60 ml and regurgitation fraction > 50 %. Regurgitation of a single heart valve may be calculated by comparing LVSV and RVSV ...

To assess the prevalence of valvular regurgitation in the aged, we studied 176 apparently healthy volunteers with no history or physical evidence of cardiac abnormality. Their ages ranged from 40 to 90 (66 ± 14, mean ± SD) years. We examined these subjects by pulsed Doppler echocardiography combined with two-dimensional echocardiography to determine the prevalence of valvular regurgitation. Reg...

To assess the accuracy of echocardiography in determining the cause of aortic regurgitation M mode and cross sectional echocardiography were compared with angiography in 43 patients with predominant aortic regurgitation. Each patient had all three investigations performed during the same admission to hospital. In each instance, the cause of aortic regurgitation was confirmed at surgery or necro...

lar contractile function in patients with long-term mitral regurgitation and normal ejection fraction. J Am Coll Cardiol 1993;22:239–250. 21. Rosenhek R, Rader F, Klaar U, Gabriel H, Krejic M, Kalbeck D, Schemper M, Maurer G, Baumgartner H. Outcome of watchful waiting in asymptomatic mitral regurgitation. Circulation 2006;113:2238–2244. 22. Zoghbi WA, Enriquez-Sarano M, Foster E, Grayburn PA, K...

Valvular heart disease is a multifactorial disorder. Twin studies may help to better understand both genetic and environmental determinants contributing to the development of valve lesions. We describe the case of a 45-year-old female asymptomatic triplet with multiple valvular heart lesions, with a somewhat different pattern between the dizygotic twin pairs compared with the monozygotic twin p...

Valvular heart disease presents as mixed spectrum lesion in healthcare settings in the third-world and developing countries. Rheumatic heart disease still forms the bulk of the aetiopathology of valve lesions. Mitral and aortic valve lesions top the list of valvular pathology. A thorough understanding of the pathophysiology of valvular heart disease is essential while planning anaesthesia and p...