Mesangial cell proliferation and growth factor over-expression are characteristic features of several glomerular diseases. Vascular endothelial growth factor (VEGF), a potent mitogen, is expressed in podocytes in the glomerulus, and VEGF receptors (flt-1, KDR, and neuropilin-1) are present on endothelial cells and other cell types. This study examined whether human mesangial cells (HMC) express...

Background: Vascular endothelial growth factor (VEGF) have a vital role in the molecular genetic eventsof angiogenesis and vasculogenesis, so it is involved development of cancer. Single nucleotidepolymorphisms (SNP) VEGF gene has been announced as risk colorectal Bevacizumab(BEV) an inhibitor that curb binding to its receptors obstructing angiogenesisprocess. Objective: The ideal goal ongoing ...

Vascular endothelial growth factor (VEGF) is primarily known as a proangiogenic factor and is one of the most important growth and survival factors affecting the vascular endothelium. However, recent studies have shown that VEGF also plays a vital role in the immune environment. In addition to the traditional growth factor role of VEGF and VEGF receptors (VEGFRs), they have a complicated relati...

Research question Maternal alcohol consumption produces fetal retardation and malformations, probably associated with placental defects. Does perigestational up to organogenesis lead abnormal placentation embryo growth restriction by disrupting the vascular endothelial factor (VEGF) system in embryo–placental development? Design Female mice were treated 10% ethanol drinking water before day 10 ...

10 REVIEW OF THE LITERATURE 12 1. The VEGF family 12 1.1. Growth factors 1.1.1. Vascular endothelial groth factor (VEGF-A) 12 1.1.2. VEGF-B 13 1.1.3. VEGF-C 13 1.1.4. VEGF-D 15 1.1.5. VEGF-E 16 1.2. The VEGF receptors 16 1.2.1. VEGFR-1 (or FLT1) 17 1.2.2. VEGFR-2 (KDR) 17 1.2.3. NEUROPILIN-1 (or receptor for VEGF165) 17 1.2.4. VEGFR-3 (or Flt4) 19 2. The Angiopoietin/Tie family 19 2.1. Growth f...

Purpose. Vascular endothelial growth factor (VEGF) binds to oorneal endothelial cells (BCE). We screened BCE for the expression of the VEGF receptors KDRIFLK-I and FLT-1 and analysed their functions. Methods. The expression of KDRIFLK-1 and FLT-1 mRNA was analysed by northern-blot. BCE were also transfeoted with expression vectors carriing the VEGF receptors sequences. Their ability to prolifer...

Purpose. Vascular endothelial growth factor (VEGF) binds to oorneal endothelial cells (BCE). We screened BCE for the expression of the VEGF receptors KDRIFLK-I and FLT-1 and analysed their functions. Methods. The expression of KDRIFLK-1 and FLT-1 mRNA was analysed by northern-blot. BCE were also transfeoted with expression vectors carriing the VEGF receptors sequences. Their ability to prolifer...

Vascular endothelial growth factor (VEGF) is a potent angiogenic polypeptide that activates 2 distinct high-affinity tyrosine kinase receptors, flk-1/KDR and flt-1. In the present study, we characterized the expression of VEGF and its receptors flk-1/KDR and flt-1 in the normal human pancreas and in human pancreatic cancer tissues and cell lines. VEGF, flk-1/KDR and flt-1 mRNA levels were eleva...

Angiogenesis plays an important role in solid tumor growth, progression and metastasis. Evidence suggests that the progression of hematolymphoid malignancies also depends on the induction of new blood vessel formation under the influence of acute leukemia, myelodysplastic syndromes, myeloproliferative neoplasms, multiple myeloma and lymphomas. The...

background angiogenesis is an important biological process involved in the proliferation of endothelial cells, tumor growth and metastasis. vascular endothelial growth factor (vegf) is considered as a prominent regulator of angiogenesis which exerts the aforementioned effect(s) through its respective receptors (vegfr1 and vegfr2). vegf receptors are targeted as a therapeutic candidate for cance...