BACKGROUND Venoms of two cobras, four vipers, a standard antibiotic and an antimycotic, were evaluated comparatively, as antimicrobials. METHODS Six venom concentrations and three of the standard antibiotic and the antimycotic were run in micro-dilution and diffusion plates against the microorganisms. RESULTS Echis pyramidum, Echis coloratus and Cerastes cerastes gasperettii highest venom c...

Snake venoms are complex mixtures of proteins of both enzymes and nonenzymes, which are responsible for producing several biological effects. Human envenomation by snake bites particularly those of the viperid family induces a complex pathophysiological picture characterized by spectacular changes in hemostasis and frequently hemorrhage is also seen. The present work reports the ability of six ...

Hump-nosed pit vipers (Genus Hypnale) are venomous snakes from South India and Sri Lanka. Envenoming by Hypnale species may cause significant morbidity and is characterized by local envenoming and less commonly coagulopathy and acute renal failure. Currently there are three nominal species of this genus: H. hypnale, H. zara and H. nepa. This study investigates the biochemical and pharmacologica...

Achyrocline satureioides is popularly known for its richness in phenolic compounds and medicinal properties (anti-inflammatory, analgesic, hepatoprotective). The present study aimed at broadening the knowledge about pharmacological potential exerted by aqueous ethanolic extracts of A. satureioides. These were characterized HPLC tested their modulatory action on phospholipases A2 proteases snake...

UNLABELLED We report a genus-wide comparison of venom proteome variation across New World pit vipers in the genus Agkistrodon. Despite the wide variety of habitats occupied by this genus and that all its taxa feed on diverse species of vertebrates and invertebrate prey, the venom proteomes of copperheads, cottonmouths, and cantils are remarkably similar, both in the type and relative abundance ...

Since the haemolysins of the several venoms respond differently to photodynamic action, they may be regarded as possessing different chemical constitutions. As regards stability, cobra haemolysin ranks first, daboia second, and Crotalus third. The toxicity of all the venoms is more or less diminished by eosin and erythrosin in sunlight. This reduction in toxicity depends upon chemical changes, ...

In this study, Mesobuthus gibbosus and Mesobuthus eupeus eupeus venom samples were compared for lethality, in vivo effects and proteins. Neutralization capacity of monovalent Androctonus crassicauda antivenom (RSHA anti-Ac) was tested against the lethal effects of the venoms.Venom was obtained from mature scorpions by electrical stimulation of the telson. The lethality of the venom and potency ...

HONOURS PROJECTS 2012 (at September 29 2011) Labs/ Supervisor(s) Project Title: ON CAMPUS PROJECTS Venoms & Toxins Labs: Hodgson/Fry Konstantakopoulos/ Hodgson/Isbister  Molecular toxinology of Australia’s lesser known venomous snakes  Profiling Australian and Malaysian snake venoms to guide treatment strategies. VascularBiology & Immunopharmacology Labs: Drummond//Sobey/Lim Kemp-Harper/Drummond

Snake envenomation has been estimated to affect 1.8 million people annually with about 94,000 deaths mostly in poor tropical countries. Specific antivenoms are the only rational and effective therapy for these cases. Efforts are being made to produce effective, affordable and sufficient antivenoms for these victims. The immunization process, which has rarely been described in detail, is one ste...