BACKGROUND Pressure-support ventilation (PSV) is more comfortable than volume controlled-continuous mandatory ventilation (VC-CMV) in acute hypercapnic respiratory failure, in patients undergoing noninvasive ventilation. Physiologic measurements of patient status have been compared in PSV and VC-CMV in endotracheally intubated patients, but patient perception of comfort has not been measured in...

Although the trend in the neonatal intensive care unit is to use noninvasive ventilation whenever possible, invasive ventilation is still often necessary for supporting pre-term neonates with lung disease. Many different ventilation modes and ventilation strategies are available to assist with the optimization of mechanical ventilation and prevention of ventilator-induced lung injury. Patient-...

Methods A set of mathematical models including pulmonary gas exchange, acid-base chemistry of blood and cerebrospinal fluid, blood oxygenation, O2 and CO2 transport and storage, ventilation, muscle function and chemoreflex respiratory drive were combined. The set of models was used to simulate changes in support during volume and pressure support ventilation. The model set was evaluated in 12 a...

Airway pressure release ventilation is a recently described method of ventilatory support. It allows spontaneous ventilation with CPAP but differs from conventional ventilatory modes because, with APRV, peak inflation pressure never exceeds the level of CPAP, and airway pressure decreases, rather than increases, when tidal volume is delivered. The risk of pulmonary barotrauma and adverse hemody...

BACKGROUND Average volume-assured pressure support (AVAPS) has been introduced as a new additional mode for a bilevel pressure ventilation (BPV) device (BiPAP; Respironics; Murrysville, PA), but studies on the physiologic and clinical effects have not yet been performed. There is a particular need to better define the most efficient ventilatory treatment modality for patients with obesity hypov...

Changes in minute ventilation, tracheal airway pressure and lung volume have been measured using a jet ventilator (VS 600) during different rates of ventilation, I:E ratios and driving pressures. A lung model with a slightly increased compliance and an increased airway resistance was used. Five rates of ventilation (from 60 to 230 b.p.m.), three I:E ratios (0.25, 0.43, 0.67) and three driving p...

INTRODUCTION The purpose of the present study was to critically review the existing body of evidence on ventilation modes for infants and children up to the age of 18 years. METHODS The PubMed and EMBASE databases were searched using the search terms 'artificial respiration', 'instrumentation', 'device', 'devices', 'mode', and 'modes'. The review included only studies comparing two ventilatio...

RATIONALE The importance of applying high-frequency oscillatory ventilation with a high lung volume strategy in infants is well established. Currently, a lack of reliable methods for assessing lung volume limits clinicians' ability to achieve the optimum volume range. OBJECTIVES To map the pressure-volume relationship of the lung during high-frequency oscillatory ventilation in infants, to de...