A decade ago, small observational studies using light transmittance aggregometry suggested that post-stenting ischemic event occurrences were not linearly related to ontreatment platelet reactivity (OPR) levels but instead largely occurred above a moderate threshold level (1,2). For example, in the CREST (Carotid Revascularization Endarterectomy Versus Stenting Trial) study of 20 patients with ...

Dilating HIV vasculopathy can be a cause of ischemic and hemorrhagic stroke in patients with HIV. Although first identified in children, this condition is increasingly being recognized in adults and has a dismal natural history under medical or expectant management. Vessel wall invasion by varicella zoster virus, HIV or Mycobacterium avium intracellulare complex (MAI) has been postulated as a p...

Background Whether high platelet reactivity (HPR) at the time of angiography is associated with worse myocardial reperfusion after primary percutaneous coronary intervention (PPCI) for ST-segment elevation myocardial infarction (STEMI) is unknown. This study aimed to assess the impact of HPR on infarct size and reperfusion injury determined by cardiac magnetic resonance (CMR) in patients with S...

Abstract Background Dual antiplatelet therapy (DAPT) is necessary for stent assisted coiling. However, long term use of DAPT has a potential risk hemorrhagic events. We aimed to examine the relationship between clopidogrel reactivity and complications. Methods Patients who underwent coiling unruptured aneurysms or previously treated received periprocedural in our institution August 2011 March 2...

aggregometry (LTA) is the most widely reported ex vivo technique to assess aspirin effect in platelets (1–3). With respect to our study potentially underestimating aspirin resistance in patients with unstable coronary syndromes, it should be noted that 23% (n 47) of our percutaneous coronary intervention (PCI) patients were in that category. All of these patients were sensitive to aspirin (4). ...

Haemostasis is a complex process affected by many factors including both cellular and plasma components. It is a multistep process starting with platelet adhesion to damaged endothelium and ending in clot fibrinolysis. There are several methods available to study different aspects of haemostasis including adhesion, aggregation, coagulation and fibrinolysis. This review describes the different m...

The aim of the present study was to investigate the effect of genetic polymorphisms in candidate genes within the leukotriene (LT) pathway on platelet reactivity and the concentration of selected LTs in diabetic patients treated with acetylsalicylic acid (ASA). The study cohort consisted of 287 Caucasians with type 2 diabetes who had received treatment with ASA tablets (75 mg/day) for at least ...