Objective: To investigate the number of intra-epithelial lymphocytes in the duodenal mucosal biopsies of patients with non specific duodenitis, clinically labelled cases of celiac disease and in normal duodenal mucosa. Material and Methods: The study included three groups. A total of 73 duodenal biopsies received in the department of histopathology, PIMS (Pakistan Institute of Medical Sciences)...

Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal (GI) manifestations and an increased risk of gastric malignancy. We report a case of a CVID with mild anemia presenting with multiple GI manifestations: gastric low-grade dysplasia (LGD), enteropathy with villous atrophy, refractory Giardia infection, nodular lymphoid hyperplasia, a...

The authors report a case of coeliac disease occurring during the pregnancy. The occurrence of coeliac disease during a pregnancy is an unusual pathology needing an early diagnostic and specific therapeutic so that the life of the child is not at stake. The diagnostic is suggested by the duodenoscopy visualizing the typical mosaic appearance of the mucosa. It's confirmed by the results of biops...

A jejunal biopsy specimen from an asymptomatic 35 year old man was studied because of a low serum titre of reticulin antibody and the finding of coeliac disease in his son. In this specimen villous structure was quite normal as was the total number of intraepithelial lymphocytes, but the number of y/b T cell receptor bearing lymphocytes was 10 times higher than the mean in control subjects. Two...