Vinflunine is a novel Vinca alkaloid presently in Phase I clinical trials. In preclinical studies, it exhibited superior antitumor activity to that of other Vinca alkaloids, including vinorelbine from which it was synthetically derived. Vinca alkaloids appear to inhibit cell proliferation by affecting the dynamics of spindle microtubules. Here we have analyzed the effects of vinflunine and vino...

Vinflunine is a novel Vinca alkaloid presently in Phase I clinical trials. In preclinical studies, it exhibited superior antitumor activity to that of other Vinca alkaloids, including vinorelbine from which it was synthetically derived. Vinca alkaloids appear to inhibit cell proliferation by affecting the dynamics of spindle microtubules. Here we have analyzed the effects of vinflunine and vino...

Vinca rosea (Catharanthus roseus L.) is native to the Caribbean Basin and has historically been used to treat a wide assortment of diseases. European herbalists used the plant for conditions as varied as headache to a folk remedy for diabetes. The objective of the study is to evaluate the diabetic wound healing activity of Vinca rosea using the excision wound model in a streptozotocin induced d...

Tubulin vinca-domain ligands can inhibit microtubule polymerization, causing cell death in mitosis, and their potential against multiple cancer types has been demonstrated. However, due to drug resistance toxicities, development of novel is still needed. In this study, we determined the high-resolution crystal structures vinorelbine, YXD, Phomopsin A complex with tubulin at 2.5 Å. Additionally,...

Vinca alkaloids used in anticancer therapy are the well-known vinblastine and vincristine as classical antitumor agents. These dimeric molecules consist of two monomers, vindoline catharanthine, which have no particular activity on their own. The goal our research work was to obtain derivatives one these, vindoline, resulted with important antiproliferative effect. This type were hybrids; conju...

Vinflunine is a novel fluorinated Vinca alkaloid currently in Phase II clinical trials, which in preclinical studies exhibited superior antitumor activity to that of two clinically useful Vinca alkaloids, vinorelbine and vinblastine. All three of the drugs block mitosis at the metaphase/anaphase transition, leading to apoptosis. The mechanism of the mitotic block is not known. On the basis of r...

Vinca alkaloids are used widely in the treatment of both childhood and adult cancers. Their cellular target is the beta-tubulin subunit of alpha/beta-tubulin heterodimers, and they act to inhibit cell division by disrupting microtubule dynamics. Despite the effectiveness of these agents, drug resistance is a major clinical problem. To identify the underlying mechanisms behind vinca alkaloid res...

HomePlant DiseaseVol. 105, No. 7First Report of Leaf Blight Caused by Phytophthora ramorum on Periwinkle (Vinca minor) in Washington State, U.S.A. PreviousNext DISEASE NOTE OPENOpen Access licenseFirst U.S.A.M. Elliott, L. Rollins, T. Bourret, and G. ChastagnerM. Elliott†Corresponding author: M. Elliott; E-mail Address: [email protected]://orcid.org/0000-0002-5754-8881Department Plant Path...