The development of methods to improve drug delivery for use in life-threatening diseases such as cancer and viral infections is urgently needed. Some drugs that have a system the central nervous are mostly into active targeted delivery. related human which complex, highly specialized interconnected network nerves. functions include: coordinating, interpreting controlling interaction between ind...

nanoparticles have been at the center of research focus as a new promising material for the treatment of cancer in recent years. although many chemotherapy drugs for cancer treatment are available, their potential toxicity is the main point of concern. on the other hand, the conventional chemotherapeutic approach has not been found to be very efficient in colorectal cancer (crc) as the drug mol...

since its original conception in 1959, by nobel physicist richard p feynman, the notion of nanotechnology and its potential ramifications have not only created fascination,but also intense scientific efforts and scrutiny. one of the most promising applications of nanotechnology is in the context of medicine. due to their unique size-dependent properties nanomaterials such as nanoparticles offer...

background: several multiphase flow analyses have been developed to predict the fate of particles used in inhalation drug delivery; however, the collapse of droplets during their passage through respiratory tract has not been investigated. objective: to assess the probability of droplet collapse in the upper respiratory tract. methods: a 3d model of mouth-to-second generation airway after the t...

conclusions it was shown that combination of pectin and eudragits can relatively control drug release in the upper gi. on the other hand, pectin degraded in the presence of pectinase and formulations were susceptible to the colonic media. results it was shown that in the presence of pectin, formulations without erl had a relative resistance to drug release in sgf. pellets containing pectin and ...

a. Specific Aims Advancements in both neuroscience and engineering have provided neurosurgery with new paradigms for the restoration of neural function. In particular, the dual emergence of accurate stereotaxis and deep brain stimulation (DBS) have generated a revolution in the application of targeted neuromodulation. DBS allows for focused reversible inhibition of neural function, while advanc...

Non-viral vectors need to overcome several barriers such as the plasma membrane, the endosomal membrane and the nuclear membrane for efficient gene delivery to the nucleus of target cells. To overcome these obstacles, the delivery system must be equipped with various functional devices. However, it is difficult to package all these needed devices into a single system to exert each of their func...

Integrating viral gene delivery with engineered biomaterials is a promising strategy to overcome a number of challenges associated with virus-mediated gene delivery, including inefficient delivery to specific cell types, limited tropism, spread of vectors to distant sites, and immune responses. Viral vectors can be combined with biomaterials either through encapsulation within the material or i...

Background: Despite the tremendous progress in human medicine, viral infections can cause death in them. Due to the high prevalence of viruses, it is required to develop novel treatment strategies and provide the site-specific delivery of antiviral agents at the viral reservoirs. Objectives: Particle size is a vital physical characteristic that can affect the bioavailability and circulation ti...