نتایج جستجو برای: viral mutation
تعداد نتایج: 430342 فیلتر نتایج به سال:
There is considerable HIV-1 variation in patients. The extent of the variation is due to the high rate of viral replication, the high viral load, and the errors made during viral replication. Mutations can arise from errors made either by host DNA-dependent RNA polymerase II or by HIV-1 reverse transcriptase (RT), but the relative contributions of these two enzymes to the mutation rate are unkn...
BACKGROUND Despite the availability of several direct-acting antivirals (DAAs) specifically inhibiting different HCV proteins, treatment of chronic HCV infection is still a challenge also because of the possible selection of resistant viral variants under DAA therapy. Indeed, only the emergence of viruses resistant to the nucleoside inhibitors of the HCV NS5B polymerase (Pol) has not yet been r...
In RNA viruses, mutations occur fast and have large fitness effects. While this affords remarkable adaptability, it can also endanger viral survival due to the accumulation of deleterious mutations. How RNA viruses reconcile these two opposed facets of mutation is still unknown. Here we show that, in human immunodeficiency virus (HIV-1), spontaneous mutations are not randomly located along the ...
INTRODUCTION An increasing number of targeted drugs have been tested for the treatment of nasopharyngeal carcinoma (NPC). However, targeted therapy-related oncogenic mutations have not been fully evaluated. This study aimed to detect targeted therapy-related oncogenic mutations in NPC and to determine which targeted therapy might be potentially effective in treating NPC. METHODS By using the ...
Detection of pathogens with single-nucleotide variations is indispensable for the disease tracing, but remains technically challenging. The D614G mutation in SARS-CoV-2 spike protein known to markedly enhance viral infectivity difficult detect. Here, we report an effective approach called “synthetic mismatch integrated crRNA guided Cas12a detection” (symRNA-Cas12a) detect D614 and G614 variants...
More than one year into a global pandemic, SARS-CoV-2 is now defined by variety of rapidly evolving variant lineages. Several FDA authorized molecular diagnostic tests have been impacted viral variation, while no reports variation affecting antigen test performance occurred to date. While determining the analytical sensitivity Quidel Sofia SARS Antigen FIA (Sofia 2), we uncovered high load spec...
Corona virus disease 2019 (COVID-19) endemic has havoc on the world; causative of pandemic is SARS CoV-2. Pharmaceutical companies and academic institutes are in continuous efforts to identify anti-viral therapy or vaccines, but most significant challenge faced highly evolving genome CoV-2, which imparting evolutionary selective benefits virus. To understand viral mutations, we have retrieved n...
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