We report the case of a man 47-year-old, with Human Immunodeficiency Virus (HIV) and Hepatitis C Virus (HCV) infection diagnosis since 1998. When he was twenty, he had been intravenous drug user. In November 2006 he had 608 lymphocytes CD4/μl and a viral load of 12.600 cop/ml of HIV, without antiretroviral treatment (ART), but a HCV viral load of 5.000.000 UI/ml, genotype 1 and portal hypertens...

Patients harbouring drug-resistance viruses usually suffer a rise in serum viraemia after a variable period of time. We have investigated the relationship between the appearance of resistant genotypes and the viral load of each patient after treatment. Our objective was to assess the association between human immunodeficiency virus (HIV) RNA plasma levels and the number of drug resistance-assoc...

In recent years, porcine epidemic diarrhea virus (PEDv) has caused major epidemics, which has been a burden to North America's swine industry. Low infectious dose and high viability in the environment are major challenges in eradication of this virus. To further understand the viability of PEDv in the infected manure, we longitudinally monitored survivability and infectivity of PEDv in two open...

We consider optimal dynamic multidrug therapies for human immunodeficiency virus(HIV) type 1 infection. We describe an optimal tracking problem attempting to move the state of the system from an “unhealthy” state (high virus load and low immune response) to a “healthy” one (with low viral load and high immune effector levels). We consider feedback control with full state as well as with partial...

A very important question in immunology is to determine which factors decide whether an immune response can efficiently clear or control a viral infection, and under what circumstances we observe persistent viral replication and pathology. This paper summarizes how mathematical models help us gain new insights into these questions, and explores the relationship between antiviral therapy and lon...

2354. Torque Teno Virus (TTV) and Epstein–Barr Virus (EBV) Viral Load in Peripheral Blood as a Biomarker of “Net Immunosuppression”: Factors Influencing Viral Load in Adult Patients Awaiting Solid Organ Transplantation Jutta Preiksaitis, MD, FRCP (C); Curtis Mabilangan, BSc; Yupin Tong, PhD; Catherine Burton, MD MSc and Simon Urschel, MD; Medicine, Infectious Diseases, University of Alberta, Ed...

INTRODUCTION In this study, we evaluated hepatitis C virus (HCV) and human immunodeficiency virus (HIV) - platelet interactions in vitro as well as human platelets antigen (HPA) polymorphisms. METHODS Platelets were obtained from 100 healthy HPA-genotyped volunteer donors and incubated with HIV or HCV. The viral load after in vitro exposure was detected. RESULTS The viral load in the platel...

A highly sensitive, non-probe-based, real-time quantitative reverse transcriptase PCR was developed for viral load measurements in both serum and liver samples from patients with hepatitis C virus (HCV) infection. With synthetic RNA, the linearity of the approach was conserved over a wide range of HCV copy numbers. There was a strong correlation between hepatic and serum viral load measurements...