In a previous communication (l), an accumulation of oxaloacetic acid was implicated as the cause of a decline of succinate oxidation in liver mitochondria from rats fed a diet deficient in vitamin E. This conclusion appeared justified from observations that compounds known to accelerate the removal of oxalo.acetate would relieve this decline of succinate oxidation. There was, however, a lack of...

Mitoxantrone (MIT) is a chemotherapeutic agent with promising anticancer efficacy. In this study, Pluronic F68-vitamine E succinate (F68-VES) amphiphilic polymer micelles were developed for delivering MIT and enhancing its anticancer activity. MIT-loaded F68-VES (F68-VES/MIT) micelles were prepared via the solvent evaporation method with self-assembly under aqueous conditions. F68-VES/MIT micel...

NAG-1 (nonsteroidal anti-inflammatory drug-activated gene), a member of the transforming growth factor-beta superfamily, is involved in many cellular processes, such as inflammation, apoptosis/survival, and tumorigenesis. Vitamin E succinate (VES) is the succinate derivative of alpha-tocopherol and has antitumorigenic activity in a variety of cell culture and animal models. In the current study...

The relation of vitamin E deficiency diseases to the possible function of tocopherol as a catalyst in enzyme systems is at present unknown. A characteristic metabolic disturbance, respiratory decline, has been described in liver slices from rats on vitamin E-deficient diets which produce necrotic liver degeneration (l-3). The deficiency disease, which is produced conveniently by diets containin...

background: nonalcoholic fatty liver disease (nafld) is the most common chronic liver disease in the world. oral administration of symbiotic and vitamin e has been proposed as an effective treatment in nafld patients. this study was carried out to assess the effects of symbiotic and/or vitamin e supplementation on liver enzymes, leptin, lipid profile, and some parameters of insulin resistance (...

BACKGROUND Nowadays, many cytotoxic anticancer drugs exhibit low solubility and poor tumor selectivity, which means that the drug formulation is very important. For example, in the case of paclitaxel (PTX), Cremophor EL(®) (BASF, Ludwigshafen, Germany) needs to be used as a solubilizer in its clinical formulation (Taxol(®), Bristol-Myers Squibb, New York, NY), although it can cause serious side...

Tumor-targeted delivery system has been developed as an attractive strategy for effective tumor therapy. In this study, in order to enhance the antitumor effects of doxorubicin (DOX), amphiphilic hyaluronic acid (HA)-conjugated vitamin E succinate (VES) copolymers (HA-VES) with different degrees of substitution (DS) were prepared with synergistic antitumor effects and active targeting activitie...

Overexpression of erbB2 is associated with resistance to apoptosis. We explored whether high level of erbB2 expression by cancer cells allows their targeting using an erbB2-binding peptide (LTVSPWY) attached to the proapoptotic alpha-tocopheryl succinate (alpha-TOS). Treating erbB2-low or erbB2-high cells with alpha-TOS induced similar levels of apoptosis, whereas alpha-TOS-LTVSPWY induced grea...

Esophageal cancer is the fourth most common gastrointestinal cancer, it generally has a poor prognosis and novel strategies are required for prevention and treatment. Vitamin E succinate (VES) is a potential chemical agent for cancer prevention and therapy as it exerts anti‑tumor effects in a variety of cancers. However, the role of VES in tumorigenesis and progression of cancer remains to be e...

background: the role of oxidative stress in endosulfan-induced reproductive toxicity has been implicated. this study was performed to evaluate the possible protective effect of vitamins e and c, against endosulfan-induced reproductive toxicity in rats. methods: fifty adult male sprague–dawley rats were randomly divided into five groups (n=10 each). the groups included a control receiving vehicl...