semen quality and its relationship to fertility are major concern in animal production. the aim of this study was to assess the relationship between frozen thawed sperm characteristics and fertility following in vivo fertility through artificial insemination(ai). semen samples were collected from four buffalo bulls. semen volume and sperm concentration appeared to be significantly different (p0...

Under dilute in vitro conditions transcription factors rapidly locate their target sequence on DNA by using the facilitated diffusion mechanism. However, whether this strategy of alternating between three-dimensional bulk diffusion and one-dimensional sliding along the DNA contour is still beneficial in the crowded interior of cells is highly disputed. Here we use a simple model for the bacteri...

Wharton’s jelly mesenchymal stem cells (HWJMSCs) hold promise for myocardial regeneration, but optimal treatment regimen (preferably with a growth factor) is required to maximize functional benefits. The aim of this study was to explore the cardioprotective and angiogenesis effects of HWJMSCs combined with insulin-like growth factor-1 (IGF-1) in the treatment of acute myocardial infarction. Th...

cutaneous leishmaniasis is endemic in 88 different countries. there are an estimated 1.5 million new cases each year, with over 90% occurring in afghanistan, algeria, iran, iraq, saudi arabia, syria (old world) and in brazil and peru (new world). miltefosine is effective in vitro and in vivo against leishmania species and it was demonstrated efficacy in animals via the oral route. this study is...

Objective(s): Investigation of acute effect on cellular bioenergetics provides the opportunity to characterize the possible adverse effects of drugs more comprehensively. This study aimed to investigate the changes in biochemical and biophysical properties of heart mitochondria induced by captopril and nifedipine antihypertensive treatment. Materials and Methods: Male, 12-week-old Wistar rats i...

Wharton’s jelly mesenchymal stem cells (HWJMSCs) hold promise for myocardial regeneration, but optimal treatment regimen (preferably with a growth factor) is required to maximize functional benefits. The aim of this study was to explore the cardioprotective and angiogenesis effects of HWJMSCs combined with insulin-like growth factor-1 (IGF-1) in the treatment of acute myocardial infarction. Th...

some dorema species are used in persian traditional medicine. in the present study the total extract from the roots of dorema hyrcanum koso-pol. was investigated for its in vitro (pldh assay) and in vivo (peters’ 4-days suppressive test) antiplasmodial effects and assessed for cytotoxicity against the normal cell line mdbk (mtt test). the ic50 values for a chloroquine- sensitive (3d7) and a chl...

background: the present study describes the susceptibility of prepubertal testis of mice to prooxidant induced oxidative impairments both under in vitro and in vivo exposure conditions. materials and methods: following in vitro exposure to iron (5,10 and 25 m), oxidative response measured in terms of lipid peroxidation and hydroperoxide levels in testis of pre pubertal mice (4 wk) was more robu...

In this study, a medicinal plant, Galla rhois (GR), was examined and screened for its anti-Helicobacter pylori activity. Galla rhois was extracted with 70% ethanol. Inhibitory zone tests, as in vitro assays, and an in vivo study using a Mongolian gerbil (Meriones unguiculatus) model were performed. The safety of the GR extract was then evaluated in an animal study. The Galla rhois extract demon...