نتایج جستجو برای: vntr تایپینگ
تعداد نتایج: 1809 فیلتر نتایج به سال:
BACKGROUND Carboxyl-ester lipase (CEL) contributes to fatty acid ethyl ester metabolism, which is implicated in alcoholic pancreatitis. The CEL gene harbours a variable number of tandem repeats (VNTR) region in exon 11. Variation in this VNTR has been linked to monogenic pancreatic disease, while conflicting results were reported for chronic pancreatitis (CP). Here, we aimed to investigate a po...
BACKGROUND Analysis of donor chimerism has become a routine procedure for the documentation of engraftment after allogeneic hematopoietic stem cell transplantation. Quantitative analysis of chimerism kinetics has been shown to predict graft failure or relapse. In this study, we compared the use of variable number tandem repeats (VNTR) and short tandem repeats (STR) as polymorphic genetic marker...
*Corresponding author: Mailing address: Division of Bacteriology, Chiba Prefectural Institute of Public Health, 666-2 Nitona, Chuo, Chiba, Chiba 260-8715, Japan. Tel: +81-43-266-6723, Fax: +81-43-265-5544, E-mail: [email protected] Tuberculosis is one of the major bacterial diseases in Japan (1). Advances in the molecular epidemiological analysis of this disease have greatly improved t...
To understand the genetic diversity and phenotypic resistance of Mycobacterium tuberculosis (MTB) strains isolated in Shijiazhuang. Spoligotyping and MIRU-VNTR were performed to genotype MTB isolates and drug susceptibility testing (DST) was used to obtain phenotypic resistance. The genotyping result with drug resistance profiles and clinical characteristics was assessed. A total of 422 strains...
BACKGROUND The MIRU-VNTR polymorphism and katG463 mutation are used to genotype the mycobacterium tuberculosis, but the correlation between them and INH-resistance were unknown. This study was aimed to explore whether ETRE polymorphism and katG463 mutation could predict the INH-resistance, and the relationship between ETRE polymorphism and katG463 mutation. METHODS The ETRE, katG463 mutation ...
The PER3 gene is one of the clock genes, which function in the core mammalian molecular circadian system. A variable number of tandem repeats (VNTR) locus in the 18th exon of this gene has been strongly associated to circadian rhythm phenotypes and sleep organization in humans, but it has not been identified in other mammals except primates. To better understand the evolution and the placement ...
زمینه و هدف : روش MIRU-VNTR به یکی از فراگیرترین روش‌های استاندارد شده ژنوتایپینگ مایکوباکتریوم توبرکلوزیس کمپلکس تبدیل شده است. این مطالعه به منظور تعیین ساختار ژنتیکی مایکوباکتریوم توبرکلوزیس به روش MIRU-VNTR و نیز تعیین نقش اعضای دیگر مایکوباکتریوم توبرکلوزیس کمپلکس در ایجاد بیماری سل انجام گردید. روش بررسی : این مطالعه توصیفی روی 53 جدایه حاصل از کشت باکتریایی نمونه‌های خلط و لاواژ معدی بی...
Standardized mycobacterial interspersed repetitive-unit-variable-number tandem repeat (MIRU-VNTR) typing based on 15 and 24 loci recently has been proposed for Mycobacterium tuberculosis genotyping. So far, this optimized system has been assessed in a single, 1-year population-based study performed in Germany (M. C. Oelemann, R. Diel, V. Vatin, W. Haas, S. Rusch-Gerdes, C. Locht, S. Niemann, an...
Although insulin secretion is commonly increased and glucose tolerance decreased in young obese patients, there is a wide individual variability of these parameters. We investigated whether common variants at the Kir6.2 (KCNJ11) and insulin variable number of tandem repeat (INS VNTR) loci are associated with insulin or glucose levels in 388 obese children. The E23K and INS VNTR alleles showed n...
Although variable-number tandem-repeat (VNTR) typing has gained recognition as the new standard for the DNA fingerprinting of Mycobacterium tuberculosis complex (MTBC) isolates, external quality control programs have not yet been developed. Therefore, we organized the first multicenter proficiency study on 24-locus VNTR typing. Sets of 30 DNAs of MTBC strains, including 10 duplicate DNA samples...
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