INHALT (Ziffern in Klammer hinter den Seitenzahlen verweisen auf die Heft-Nummer des 25Jg.)

A mutation of HIF-2 alpha has been detected in three generations of a family with erythrocytosis and the mutation co-segregated with the erythrocytosis phenotype. Functional studies revealed that Gly537Trp mutation would significantly impair the function of HIF-2 alpha thus leading to increased synthesis of Epo. In addition to VHL and PHD2 a further member of the oxygen sensing pathway, namely ...

Von Hippel-Lindau syndrome is a rare, genetically based, autosomal dominant disorder. Its course is accompanied by the development of multiple neoplasms with the following tumours diagnosed most commonly in the central nervous system haemangioblastoma, clear cell renal cell carcinoma, phaeochromocytomas, pancreatic islet tumours, and endolymphatic sac tumours. Additionally, renal and pancreatic...

Von Hippel Lindau is an inherited disease which leads to tumor growth, including hemangioblastomas in the central nervous system and retina. No pharmacological treatment has demonstrated efficacy. Propranolol is a beta-blocker widely used in some neurological and cardiac diseases, and its safety is known. We present a patient diagnosed with Von Hippel Lindau disease who was treated with propran...

CONTEXT Patients with von Hippel-Lindau syndrome, a dominantly inherited familial cancer syndrome, develop a variety of tumors in different organ systems which make the clinical management of these patients complex. CASE REPORT The long clinical history of a 45-year-old woman started at 22 years of age when she had surgery for a right adrenal pheochromocytoma. Two years later, a pancreaticodu...

OBJECTIVE To gather, to characterize, to analyze, to synthesize and to integrate primary studies that addressed the experiences of spouses / husbands / partners of women with breast cancer, presenting the current state of knowledge. METHOD Integrative literature review carried out in the databases of VHL, PubMed, CINHAL e SciELO. RESULTS The sample consisted of eight studies published betwe...

1 Department of Computer Science and Engineering, University of California, San Diego, CA, USA ([email protected]) 2 Department of Cognitive Science, University of California, San Diego, CA, USA ([email protected], [email protected]) 3 Frankfurt Institute for Advanced Studies, Max-von-Laue Str. 1, 60437 Frankfurt am Main, Germany 4 Los Alamos National Laboratory; CCS-1, MS-B287, Los A...

New paradigms, such as Open Innovation (Chesbrough, 2003) and Web 2.0 (O’Reilly, 2004) as well as Living Labs operating as a User Centred Open Innovation Ecosystem (Pallot, 2009), promote a more proactive role of users in the R&D process. However, a number of existing methods for involving users are abundantly described in the literature, such as Lead User (Von Hippel, 2005), User Driven Innova...

OBJECTIVES In adults, increasing numbers of adrenalectomies for pheochromocytomas are performed laparoscopically. We report for the first time laparoscopic bilateral subtotal adrenalectomy for pheochromocytomas in an 8-year-old boy with von Hippel-Lindau disease. METHODS In July 1998, an 8-year-old boy with von Hippel-Lindau disease underwent laparoscopic adrenal-sparing surgery for bilateral...

With sincere thanks to Eric von Hippel and Nana Admadjaja, the many innovators who gave graciously of their time, and my wonderful family and friends. Responsibility for all views expressed lies with the author.