BACKGROUND Transcatheter balloon valvuloplasty has been the accepted first line treatment for congenital pulmonic stenosis (PS) in children. Transcatheter closure of perimembranous ventricular septal defect (VSD) with Amplatzer VSD occluder is an alternative to surgical repair. CASE PRESENTATION A 12 year old boy presented with history of exertional dyspnea and atypical chest pain. Physical f...

BACKGROUND Ventricular septal defects (VSD) are the most common subtype of congenital heart defects (CHD) and are estimated to account for 20 to 30% of all cases of CHD. The etiology of isolated VSD remains poorly understood. Eight core aminoacyl-tRNA synthetases (ARSs) (EPRS, MARS, QARS, RARS, IARS, LARS, KARS, and DARS) combine with three nonenzymatic components to form a complex known as the...

Value Sensitive Design (VSD) seeks to design technology that accounts for human values in a principled and comprehensive manner throughout the design process (Friedman, 1997). In this paper, we show how VSD can be seen as extending Alexander’s (1979) idea of a pattern to frame a larger research and design program on human values and information technology. We briefly present the theoretical con...

Material and methods: Between December 2004 and December 2013, 300 patients with medical record of VSD were admitted to our study, previously admitted to the cath lab at our center for percutaneous treatment of their VSD with various types of devices. All patients were followed until December 2013, 1 to 109 months. VSD type treated: perimembranous (VSDpm) 93.85 % and muscular (VSDM) 6.14%. The ...

A 77-year-old female patient underwent aortic valve replacement (AVR) with concomitant septal myectomy and tricuspid annuloplasty. Her symptoms did not improve after a successful operation. Echocardiogram demonstrated the presence of an iatrogenic ventricular septal defect (VSD). It was muscular in location and not the usual AVR with membraneous type of VSD, suggesting a complication from the m...

The aim of this study was to examine how somatic mutations of the GATA4 gene contributed to the genesis of ventricular septal defect (VSD). The coding and intron-exon boundary regions of GATA4 were sequenced of DNA samples from peripheral blood cells and cardiac tissues of twenty surgically treated probands with VSD. Seven novel heterozygous variants were detected in cardiac tissues from VSD pa...

AIMS Immediate surgical repair of ventricular septal defect (VSD) complicating acute myocardial infarction is associated with high mortality. Percutaneous device closure appears to be safe and effective in patients treated for a residual shunt after initial surgical closure, as well as in patients with a chronic post-infarct VSD. Primary transcatheter VSD closure in the acute setting may also o...

Voltage-dependent K(+) (Kv) channels play crucial roles in nerve and muscle action potentials. Voltage-sensing domains (VSDs) of Kv channels sense changes in the transmembrane potential, regulating the K(+)-permeability across the membrane. Gating modifier toxins, which have been used for the functional analyses of Kv channels, inhibit Kv channels by binding to VSD. However, the structural basi...

A yearling California sea lion Zalophus californianus stranded in poor body condition, and on physical examination a heart murmur was audible bilaterally. The sea lion was diagnosed with a left-to-right shunting membranous ventricular septal defect (VSD) using B-mode, color-flow Doppler and continuous-wave Doppler echocardiography. A left-to-right intracardiac shunting lesion was confirmed duri...

Recently, various view synthesis distortion estimation models have been studied to better serve 3-D video coding. However, they can hardly model the relationship quantitatively among different levels of depth changes, texture degeneration, and (VSD), which is crucial for rate-distortion optimization rate allocation. In this paper, an auto-weighted layer representation based developed. Firstly, ...