Accumulating evidence shows that androgen receptor (AR) activation and signaling plays a key role in growth and progression in all stages of prostate cancer, even under low androgen levels or in the absence of androgen in the castration-resistant prostate cancer. Sustained activation of AR under androgen-deprived conditions may be due to its interaction with co-activators, such as p52 NF-κB sub...

The development of oil and gas production together with the fruit in nearby areas North Patagonia, Argentina, suggests aquatic pollution scenarios which include permanent combined short events pesticides application. It has been reported that hydrocarbons activate aryl hydrocarbon receptor (AhR) pathway rainbow trout, Oncorhynchus mykiss, insecticide Chlorpyrifos (CPF) interacts these effects. ...

Multi-terminal high-voltage direct current technology based on voltage-source converter stations (VSC-MTDC) is expected to be one of the most important contributors future electric power systems. In fact, among other features, it has already been shown how this can contribute improve transient stability in systems by use supplementary controllers. Along line, paper will investigate detail these...

Acute catastrophic events can cause significant damage to marine environments in a short time period and may have devastating long-term impacts. In April 2010 the BP-operated Deepwater Horizon (DWH) offshore oil rig exploded, releasing an estimated 760 million liters of crude oil into the Gulf of Mexico. This study examines the potential effects of oil spill exposure on coral larvae of the Flor...

BACKGROUND DNA damage in mammalian cells stabilizes the p53 protein which then functions as a cell cycle checkpoint by leading to growth arrest or apoptosis. p53 is a transcription factor and positively regulates the expression of the p21/WAF-1 gene and the mdm2 gene. After high-dose UV irradiation, p53 increases the expression of the p21/WAF-1 gene immediately (2 to 5 hours after irradiation) ...

Based on the Modern-Era Retrospective Analysis for Research and Applications version 2 (MERRA-2) reanalysis data from 1981 to 2020, climatological features of vertical components three-dimensional Eliassen–Palm (EP) wave activity fluxes (WAF) were investigated. The parameter is related eddy heat flux a key indicator upward downward propagation quasi-stationary planetary-scale waves. Northern He...

Abstract Owing to the significant influence of El Niño-Southern Oscillation (ENSO) on global climate, how ENSO events are initiated is an intriguing issue. The North Pacific (NPO), a primary atmospheric variability over midlatitude, well-known trigger for events, but physical linkage not yet fully understood. Based observational analyses, in Part I, we proposed new mechanism that NPO-related wa...

The Workshop of Physical Agents intends to be a forum for information and experience exchange in different areas regarding the concept of embodied agents, especially applied to the control and coordination of autonomous systems: robots, mobile robots, industrial processes or complex systems. This special issue is devoted to the selected papers presented at the WAF09 that took place from Septemb...

This paper introduce a three-stage approach that can automatically mining multi-step attack patterns from massive alert data of web application firewalls. The first stage extracts attack sequences, and the second stage clusters similar attack sequences. At the last stage we recognize an attack pattern for each cluster. We conducted our experiments on real-world WAF alert data obtained from a fa...