BACKGROUND NaV1.7 is preferentially expressed, at relatively high levels, in peripheral neurons, and is often referred to as a "peripheral" sodium channel, and NaV1.7-specific blockers are under study as potential pain therapeutics which might be expected to have minimal CNS side effects. However, occasional reports of patients with NaV1.7 gain-of-function mutations and apparent hypothalamic dy...

Oxytocin (OT) and vasopressin (VP) can profoundly affect animal physiology and behavior. Over the past 20 years, the genes that encode OT and VP, as well as their respective receptors, have been identified and intensively studied leading to a greater understanding of the hormones’ functions. The use of transgenic animals, including knockout mice, and viral vectors have opened new vistas of rese...

A challenge for educators is to fuse the learning of information literacy to an academic education in such a way that the outcome is systematic and sustainable learning for students. This challenge can be answered through longterm commitment to information literacy education bound to organisation-wide, renewable strategic planning and driven through systemic reform. This paper explores the proc...

Dialogism provides the grounds for building a comprehensive model of discourse and it is focused on the multiplicity of perspectives (i.e., voices). Dialogism can be present in any type of text, while voices become themes or recurrent topics emerging from the discourse. In this study, we examine the extent that differences between self-explanations and thinkalouds can be detected using computat...

Estrogen formation from androst-4-ene-3,17-dione and its kinetics were studied using microsomes from rat hypothalamus. [4-14C] androst-4-ene-3,17-dione and a homogenate of rat hypothalamus were incubated in the presence of NADPH at 37 degrees C for 3 hrs. The estrogen fraction was extracted from the incubation mixture with ethyl acetate, purified by column chromatography on Sephadex LH-20 and B...

BACKGROUND The hypothalamic nuclei constitute that part of the corticodiencephalic mechanism that activates, controls and integrates the peripheral, autonomic mechanisms, endocrine activity and many somatic functions. Their full integration into behavior requires the neocortex, in particular the limbic system. PURPOSE An antiserum against histamine was used to reveal the location and time of ...

Using rainbow trout (Oncorhynchus mykiss) as a model, we aimed to obtain information about the gastrointestinal tract (GIT) amino acid sensing capacity and hormone production along regions of GIT, in response proline (Pro), solution free acids (FAA) mimicking composition fishmeal (FM) aqueous extract (FM-FAA), or whole FM (FM-AQE). In addition, evaluated central responses (in hypothalamus) mech...