OBJECTIVE To determine the optimal methotrexate dose in individual patients and to explore whether this optimal dose and the level of disease activity at that dose could be predicted. METHODS Data from CAMERA II trial comparing MTX and MTX with 10 mg of prednisone both in a tight control treatment strategy in early RA was used. For each patient a curve for disease activity over time was fitte...

A 61-year-old male presented with a rapidly progressive exophthalmos from small cell lung cancer metastatic to the right orbit. His vision in that eye was 20/200, and his intraocular pressure was 36 mmHg. The orbital metastasis responded dramatically to chemotherapy. One week after starting the chemotherapy the patient did not have exophthalmos, his vision was 20/20, and three weeks later the i...

Open Access Week, starting 24 October 2016, is a worldwide event established to promote the potential benefits of open access and to foster wider participation in helping to make open access the norm in research and information sharing. In its eighth year, Open Access Week presents an opportunity for funding bodies, universities and others to use the context to advance policy changes in favour ...

The present investigation deals with the bulk arrival M/G/1 retrial queue with impatient customers and modified vacation policy. The incoming customers join the virtual pool of customers called orbit if they find the server being busy, on vacation or in broken down state otherwise the service of the customer at the head of the batch is started by the server. The service is provided in k</em...

Matthiola incana (Brassicaceae) is an important ornamental plant, which is used as cut flower, pot plant, and landscape. Traditionally, it is propagated via seeds, but interest is given in vegetative propagation of parental lines as well as superior single plants. Micropropagation by organogenesis is an efficient in vitro propagation method for Matthiola incana. Starting from seeds, apical bud ...