Insulin resistance in skeletal muscle is found in obesity and type 2 diabetes. A mechanism for impaired insulin signaling in peripheral tissues is the inhibition of insulin action through serine phosphorylation of insulin receptor substrate (Irs) proteins that abolish the coupling of Irs proteins to the activated insulin receptor. Recently, we described serine-318 as a protein kinase C (PKC)-de...

Obesity is an important and intractable public health problem. In addition to the well-known risk factors of behavior, diet, and genetics, gut microbial communities were recently identified as another possible source of risk and a potential therapeutic target. However, human and animal-model studies have yielded conflicting results about the precise nature of associations between microbiome com...

Recently, a proliferation of athletic supplements has been marketed touting boron as an ergogenic aid capable of increasing testosterone. The effect of boron supplementation was investigated in male bodybuilders. Ten male bodybuilders (aged 20 to 26) were given a 2.5-mg boron supplement, while nine male bodybuilders (aged 21 to 27) were given a placebo for 7 weeks. Plasma total and free testost...

Lean production has become an integral part of the manufacturing landscape as its link with superior performance and its ability to provide competitive advantage is well accepted among academics and practitioners. Lean production helps producers in overcoming the challenges organizations face through using powerful tools and enablers. However, most companies are faced with restricted resources ...

Recently, environmental concern and demand for a catalyst’s high performance have increased and many research activities focused on the operation of a three-way catalyst (TWC) at the end of its lifetime. Catalyst aging is the loss of catalytic activity over time that has crucial importance in emission of three-way catalyst.  The aim of this paper is, investigating experimentally the performanc...

Objective: We have recently identified secretory leukocyte peptidase inhibitor (SLPI), a component of the innate host defence in human omental adipose tissue. The objective of this study was to determine if the SLPI secreted by adipose tissue is regulated by changes in obesity. Materials/Methods: Circulating SLPI was measured in lean/overweight (n = 13), obese (n = 10) and obese diabetic (n = 1...

To understand how body composition relates to functional impairment, the authors examined cross-sectional associations of absolute and relative measures of fat and lean mass with physical performance and self-reported functional limitation. The sample consisted of a community-based cohort of 1,655 older women and men from Sonoma, California, who had complete baseline data in 1993-1994 on body c...

This study attempted to discover why feline CaOx urolithiasis prevalence has recently increased. By offering 3 different diets, the researchers investigated differences in UOx excretion. HP was associated with slightly more acidic and concentrated urine, with no significant difference in UOx excretion. Several limitations were present; for instance, young adult, intact, lean, female cats were u...

Neoplastic disease continues to represent one of the most formidable challenges in modern medicine. Many neoplastic lesions stem from the cumulative outcome of a variety of genetic mutations, allowing cells to rely on multiple and often redundant pathways to sustain undesirable growth [1]. In contrast, several forms of leukemia appear to result from unique translocation events that lead to the ...

The ability to compress sentences while preserving their grammaticality and most of their meaning has recently received much attention. Our work views sentence compression as an optimisation problem. We develop an integer programming formulation and infer globally optimal compressions in the face of linguistically motivated constraints. We show that such a formulation allows for relatively simp...