The World Health Organization (WHO) has produced guidelines for the management of common illnesses in hospitals with limited resources. This series reviews the scientific evidence behind WHO’s recommendations. The WHO guidelines, and more reviews are available at http://www.ichrc.org This review addresses the question: What is the Most Effective Antibiotic Regime for Chronic Suppurative Otitis ...

Most laboratory assays take advantage of multi-step protocols to achieve high performance, but conventional paper-based tests (e.g., lateral flow tests) are generally limited to assays that can be carried out in a single fluidic step. We present a method to automate multi-step chemical delivery in a simple paper device via a single user activation step. A fluid well is used as a buffer source t...

This article describes the development of porous two-ply channels for paper-based microfluidic devices that wick fluids significantly faster than conventional, porous, single-ply channels. The two-ply channels were made by stacking two single-ply channels on top of each other and were fabricated entirely out of paper, wax and toner using two commercially available printers, a convection oven an...

When a wetting liquid wicks into a fibrous material, it causes the material to deform. In this paper we discuss the elastocapillary effect that leads to spontaneous internal stresses in the materials. The elasto-capillary effect produced by menisci in pores can be identified through a specific stress distribution in the fibrous matrix. We show that the classical Bernoulli problem of a freely ha...

Wicking in textiles is a key property of fabric moisture permeability, which has been found to be dominant the comfort-maintaining mechanism apparel products, especially for sportswear that high requirements sweat transfer. Various methods have given order improve transfer behavior fabrics, among fiber modification most direct and ideal way. In this article, design-driven yarn structure spinnin...

Paper-based microfluidic devices are an attractive option for developing low-cost, point-of-care diagnostic tools. To incorporate more complex assays into paper, these must become sophisticated, through the sequential delivery of different liquids or reagents without user intervention. Many flow control strategies focus on slowing fluid down. However, this can lead to increased assay times and ...

A simple approach to the evaluation of blood coagulation using a microfluidic paper-based lateral flow assay (LFA) device for point-of-care (POC) and self-monitoring screening is reported. The device utilizes whole blood, without the need for prior separation of plasma from red blood cells (RBC). Experiments were performed using animal (rabbit) blood treated with trisodium citrate to prevent co...