نتایج جستجو برای: xenobiotic metabolism
تعداد نتایج: 227538 فیلتر نتایج به سال:
The basic pattern of the metabolism of foreign compounds is the same in all species, in that most foreign compounds are metabolized in two phases, in the first of which the compound may be oxidized, reduced, or hydrolyzed and in the second the products of the first phase may undergo a synthesis or conjugation to form polar excretory products. Within this pattern, however, tremendous variations ...
The study of xenobiotic metabolism has long been a core activity in pharmacology. The diverse chemical transformations of xenobiotics in vivo are elegant in themselves, depending as they do on a battery of enzymes that include the cytochomes P450 (CYPs), and their reaction mechanisms have been elucidated by a great many pioneering pharmacologists who helped to launch the discipline. Today, rese...
Individual variability in xenobiotic metabolism has been associated with susceptibility to developing complex diseases. Genes involved in xenobiotic metabolism have been evaluated in association studies; the difficulty of obtaining accurate gene frequencies in mixed populations makes interpretation of the results difficult. We sought to estimate population parameters for the cytochrome P450 and...
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