As a result of conducting questionnaire about science classes to high school students in 2016, the percentage who answered "I like science" and "Science is important" lower than other subjects. However, more 80% elementary junior said they experiments observations. In addition, 2019 smartphone penetration rate survey found that it popular among 90% students. VR technology has recently made rema...

CONTEXT Generalized anxiety disorder (GAD) is a chronic disorder in need of reliable data to guide long-term treatment. OBJECTIVES To assess the benefits of 6 and 12 months' treatment of GAD with venlafaxine hydrochloride extended release (XR) in patients who improved after 6 months' open-label venlafaxine XR treatment. DESIGN After 6 months' open-label venlafaxine XR treatment, improved pa...

OBJECTIVE Extended release (XR) and immediate release (IR) quetiapine have differing dosing, titration and plasma concentration profiles. The authors assessed whether the use of quetiapine XR and IR in schizophrenia spectrum disorders (SCZ) and bipolar disorder (BD) differ. DESIGN Retrospective non-interventional registry study. SETTING Secondary healthcare. PARTICIPANTS All SCZ and BD (I...

OBJECTIVES The atypical antipsychotic quetiapine is a first-line treatment for schizophrenia. This non-interventional study (NCT01212575) evaluated the clinical use of its two formulations, extended release (XR) and immediate release (IR), in outpatients with schizophrenia spectrum disorder. METHODS Patients who had received at least one dose of quetiapine XR and/or IR were included. A dosage...

Through improved adherence, once-monthly injectable extended-release naltrexone (XR-NTX) may provide an advantage over other oral agents approved for alcohol and opioid dependence treatment. The objective of this study was to evaluate cost and utilization outcomes between XR-NTX and other pharmacotherapies for treatment of alcohol and opioid dependence. Published studies were identified through...

A Stochastic Kinetic Model (SKM) is a continuous-time pure jump process describing the dynamic evolution of the state of the molecular network, x(t). Any change in x(t) is the result of the occurrence of some biochemical reaction, m. The stoichiometric matrix is given by S := [S1, S2, ..., SM ], where the column vector Sm consists of the changes in the number of molecules of each species caused...

Let XR be a geometrically irreducible smooth projective curve, defined over R, such that XR does not have any real points. Let X = XR×R C be the complex curve. We show that there is a universal real algebraic line bundle over XR × Pic d(XR) if and only if χ(L) is odd for L ∈ Picd(XR). There is a universal quaternionic algebraic line bundle over X × Pic(X) if and only if the degree d is odd. Tak...

(A1) Assume that there exists an asymptotically stable fixed point of (1.1) at the origin (0, 0), the eigenvalues of which are real and negative (to eliminate spirals and center directions). From (A1) the basin of attraction of (0, 0) is the entire space. Let Γ0 = R, the positive quadrant. Let Γ0 = {x(0) ∈ Γ0|x(t) ∈ R for all t ≥ 0}, namely the collection of trajectories that converge to the or...

In Part I it was shown that if G is a p-group of class k, generated by elements of orders 1 < p1 ≤ · · · ≤ pr , then a necessary condition for the capability of G is that r > 1 and αr ≤ αr−1 + ⌊ k−1 p−1 ⌋. It was also shown that when G is the k-nilpotent product of the cyclic groups generated by those elements and k = p = 2 or k < p, then the given conditions are also sufficient. We make a corr...