Male recipients of transplants from female (F-->M) hematopoietic stem cell donors represent a special group in whom donor T cells that are specific for recipient minor histocompatibility antigens encoded by Y-chromosome genes may contribute to a graft-versus-leukemia (GVL) effect and to graft-versus-host disease (GVHD). We examined the contribution of donor/patient sex to the risk for relapse a...

Targeted drug delivery offers an opportunity for the development of safer and more effective therapies for the treatment of cancer. In this study, we sought to identify short, cell-internalizing peptide ligands that could serve as directive agents for specific drug delivery in hematologic malignancies. By screening of human leukemia cells with a combinatorial phage display peptide library, we i...

There is strong clinical and epidemiolÃ3gica! evidence that ionizing radiation can cause leukemia by inducing DNA damage. This crucial initiation event is believed to be the result of random DNA breakage and misrepair, whereas the subsequent steps, promotion and progression, must rely on mechanisms of selective pressure to provide the expanding leukemic population with its proliferative/renewal...

There is strong clinical and epidemiolÃ3gica! evidence that ionizing radiation can cause leukemia by inducing DNA damage. This crucial initiation event is believed to be the result of random DNA breakage and misrepair, whereas the subsequent steps, promotion and progression, must rely on mechanisms of selective pressure to provide the expanding leukemic population with its proliferative/renewal...

REFERENCES 1. Wang SA, Hasserjian RP. Erythroid proliferations in myeloid neoplasms. Hum Pathol 2012;43:153-64. 2. Liu W, Hasserjian RP, Hu Y, et al. Pure erythroid leukemia: a reassessment of the entity using the 2008 World Health Organization classification. Mod Pathol 2011;24:375-83. 3. Liu CJ, Hong YC, Yang CF, et al. Clinicopathologic features and outcome of acute erythroid leukemia based ...

Viral cell-free DNA (cfDNA) in plasma has been widely evaluated for detecting cancer and monitoring disease virus-associated tumors. We investigated whether the amount of cfDNA human T-cell leukemia virus type 1 (HTLV-1) correlates with state adult leukemia-lymphoma (ATL). HTLV-1 aggressive ATL was significantly higher than that indolent asymptomatic carriers. Notably, patients lymphoma represe...

midface bones are an unusual site for primary presentation and relapse in acute lymphoblastic leukemia. herein, we describe a case of acute pre b cell lymphoblastic leukemia with leukemic infiltration of maxilla and bone marrow involvement. at the time of relapse, the patient presented again with maxilla involvement and the phenotype changed to biphenotypic lymphoblastic leukemia. our case sugg...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...

1. Hanchard B: Adult T-cell leukemia/lymphoma in Jamaica: 19861995. J Acquire Immune Defic Syndr Hum Retrovirol 13:S20, 1996 (suppl 1) 2. Hisada M, Okayama A, Shioiri S, Spiegelman DL, Stuver SO, Mueller NE: Risk factors for adult T-cell leukemia among carriers of human T-lymphotropic virus type I. Blood 92:3557, 1998 3. Yamaguchi K, Seiki Y, Yoshida M, Nishimura H, Kawano F, Takatsuki K: The d...