gδ T-cells contribute importantly to tumor immunosurveillance and are activated by phosphoantigen intermediates of the mevalonate pathway that are commonly over-produced in cancer cells. To potentiate this, phosphoantigen levels can be boosted using zoledronic acid (ZA). However, in vivo delivery of ZA to the tumour is inefficient owing to its poor pharmacokinetic properties. Here, we set out t...

Nextens is an open source text-to-speech system that can be used to convert Dutch text into speech as spoken in The Netherlands. Flemish is the variant of Dutch as spoken in Flanders. These two languages have the same written form, but they sound clearly different. This paper describes how we transformed the Nextens system into a Flemish speaking application. In order to achieve this goal, a hi...

Povzetek. Predstavljen je predkupni operacijski sistem, ki teče v realnem času. Prirejen je za mikrokrmilnike s procesnim jedrom ARM7. Izvorna koda za družino mikrokrmilnikov LPC123x je dostopna na svetovnem spletu [1]. Posamezne sklope operacijskega sistema, kot so npr. razvrščanje procesov, dinamično dodeljevanje pomnilnika in binarni semaforji, smo implementirali na preprost in modularen nač...

Herein, we report a rare case in which bisphosphonate zoledronic acid (ZA) effectively treated not only multiple bone metastases but also lung, pleural and liver metastases from renal cell carcinoma (RCC). Recently, ZA is used to treat skeletal-related events (SREs) such as bone pain caused by bone metastasis from many kinds of cancer. The patient in the present report had multiple bone metasta...

On the lattice, for Wilson fermions, the chiral Ward Identity is only approximately true, due to discretisation effects. We have a finite renormalisation constant ZA(g) to determine by demanding that a Ward Identity is obeyed to O(a) (with n = 2 for O(a) improved fermions). The ALPHA collaboration [1] has found ZA for quenched fermions using the Schrödinger functional and PCAC; here, alternativ...

Information-providing dialogue systems typically use one of the following dialogue strategies: finite-state based, frame-based, or agentbased. Recent extensions are concerned with hybrid models, where mixed automaton and information state approaches are combined. We report on our multimodal mobile Semantic Web access system SMARTWEB which uses a more rigid dialogue management strategy to ensure...

Povzetek. Sistemski operaterji prenosnega omrežja so z izvajanjem sistemskih storitev zadolženi za zakup energije za kritje prenosnih izgub. Zakup te energije ponavadi izvajajo na letni, mesečni in dnevni ravni. Ker zakup energije za daljše obdobje ne zadostuje nihanjem na dnevni ravni, je hitra in natančna kratkoročna napoved prenosnih izgub bistvenega pomena za ekonomično obratovanje sistema....

Zoledronic acid (ZA) is the current standard of care for the therapy of patients with bone metastasis or osteoporosis. ZA inhibits the prenylation of small guanosine‑5'-triphosphate (GTP)‑binding proteins, such as Ras, and thus inhibit Ras signaling. The present study demonstrated that ZA inhibited cell proliferation and the pentose phosphate pathway (PPP) in bladder cancer cells. In addition, ...

We investigate the prospects of detecting a Higgs pseudoscalar (A) in association with a Z gauge boson produced from bottom quark fusion (bb̄ → ZA) at the CERN Large Hadron Collider (LHC). A general two Higgs doublet model and the minimal supersymmetric standard model are adopted to study the discovery potential of pp → ZA → ll̄bb̄ + X, l = e or μ, via bb̄ → ZA with physics backgrounds and realisti...

Adresa za dopisivanje Silvana Jukić Krmek Sveučilište u Zagrebu Stomatološki fakultet Zavod za endodonciju i restaurativnu stomatologiju Gundulićeva, 10000 Zagreb Tel: +385 1 4802 126 [email protected] Sažetak Svrha: U ovom se istraživanju ispitivao antibakterijski učinak dvaju materijala za retrogradno brtvljenje korijenskog kanala testom bakterijske difuzije agara. Materijali i postupci: Ploče kr...