It has been proven that roof runoff water plays an important role in the high metallic concentration levels in urban rainwater since metallic elements are generated by corrosion of roof materials before being swept away by rainwater. The aim of TOITEAU project is therefore to model this phenomenon, evaluating the metallic flows from roofs in rainwater. To achieve this goal, an important work ha...

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BACKGROUND A growing popularity of machine learning methods application in virtual screening, in both classification and regression tasks, can be observed in the past few years. However, their effectiveness is strongly dependent on many different factors. RESULTS In this study, the influence of the way of forming the set of inactives on the classification process was examined: random and dive...

Introduction: Paracetamol is the most used drug for management of pain and as an antipyretic through its mechanism action on Cox 1,2 3 receptors. a lipid-soluble molecule that can pass Blood Brain Barrier. has been formulated differently to ensure optimal onset duration both analgesic antipyretic. overdose associated with major side effects such liver damage metaboli...

abstract due to calcareous soil conditions, zinc deficiency is a yield limiting factor for wheat production in iran. one solution for this problem is the cultivation of zn-efficient wheat varieties. ten wheat cultivars (nine bread wheat and one durum wheat) with different tolerance to zn deficiency were studied in a greenhouse experiment. plants were treated with zn (10 mg zn kg-1 soil as znso4...

In metabolomics the identity and role of low mass molecules called metabolites that are produced in cell metabolic processes are investigated. These make them valuable indicators of the phenotype of a biological system. The ‘Metabolite Space’ is the total chemical universe of metabolites present in all compartments and in all states from any organism. These molecules exhibit common features tha...

BACKGROUND Tools to explore large compound databases in search for analogs of query molecules provide a strategically important support in drug discovery to help identify available analogs of any given reference or hit compound by ligand based virtual screening (LBVS). We recently showed that large databases can be formatted for very fast searching with various 2D-fingerprints using the city-bl...

zinc sulphate is currently used for treatment of zinc deficiency. its uptake by the body is poor, necessitating the administration of high doses. this leads to a range of unpleasant side effects. in order to increase the bioavailability of zinc, several zinc complexes have been designed and synthesized using bidentate ligands of hydroxypyranones and hydroxypyridinones. elemental analysis in eac...

OBJECTIVE To review the evidence supporting complementary and alternative medicine approaches to treatment and prevention of the common cold in adults. QUALITY OF EVIDENCE MEDLINE, EMBASE, and the Cochrane Database of Systematic Reviews were searched from January 1966 to September 2009 combining the key words common cold or influenza with echinacea, garlic, ginseng, probiotics, vitamin C, and...