Apart from severe zinc deficiency in akrodermatitis enteropatika, clinical effects of more moderate zinc deficiency are diarrhea, pneumonia, behavioral problems, impaired memory, learning disability and neuronal atrophy, alopecia, growth retardation, gonadal hypofunction, abnormal pregnancy, susceptibility to infections, delayed wound healing, impaired glucose tolerance, and many others. These ...

The metallothionein gene is transcriptionally regulated by zinc. Consequently, metallothionein has potential for serving as an index of dietary zinc status in humans. To examine this possibility, an enzyme-linked immunoassay (ELISA) based on a sandwich approach that utilizes monoclonal and chicken egg yolk antibodies was used to compare the response of erythrocyte metallothionein protein levels...

Zinc deficiency, which is common in patients with cystic fibrosis (CF), can lead to several complications that may increase the number of hospital admissions in this group of patients. As supplementary zinc can prevent such complications, this study was performed to evaluate the effect of supplementary zinc on body mass index (BMI), forced expiratory volume in one second (FEV1) and number of ho...

Iron and zinc may interact in micronutrient supplements and thereby decrease efficacy. We investigated interactive effects of combined zinc and iron supplementation in a randomized controlled trial conducted in 459 Guatemalan women. Four groups were supplemented for 12 weeks: (1) weekly iron and folic acid (IFA); (2) weekly IFA and 30 mg zinc; (3) daily IFA; (4) daily IFA and 15 mg zinc. Effect...

Introduction: Cancer and chemotherapy could decrease serum Zinc level. In this study, serum Zinc level was investigated at the beginning of cancer diagnosis and 3 months after chemotherapy in children with all types of cancer. Method: In this cross sectional study forty-five 1-15 year old children who were newly diagnosed cancer cases (leukemia, lymphoma and solid tumor) were evaluated. Pat...

BACKGROUND Iron and zinc deficiency are prevalent during infancy in low-income countries. OBJECTIVES The objectives were to examine whether a weekly supplement of iron, zinc, iron+zinc, or a micronutrient mix (MM) of 16 vitamins and minerals would alter infant development and behavior. DESIGN The participants were 221 infants from rural Bangladesh at risk of micronutrient deficiencies. Deve...

BACKGROUND Childhood zinc deficiency is a common problem in many developing countries where people rely mainly on plant based diets with low zinc contents. Zinc supplementation is one of strategies to combat zinc deficiency and its consequences in children. The aim of this community trial was to examine the effect of zinc supplementation on the linear growth of children 6-24 months of age and t...

Zinc is widely recognized as an essential micronutrient with a catalytic role in over a 100 specific metabolic enzymes in human metabolism. Zinc deficiency was a major etiological factor in the syndrome of adolescent nutritional dwarfism, that had been identified mideastern countries. Zinc is one of the most ubiquitous of all trace elements involved in human metabolism and plays multiple roles ...

BACKGROUND Maternal zinc deficiency is relatively common in developing countries, but its consequences for fetal growth are not established. OBJECTIVE The goal was to examine whether improvement in maternal gestational zinc status is positively associated with fetal growth as assessed by ultrasonography. DESIGN We conducted a double-masked, randomized trial among 242 pregnant Peruvian women...

Zinc deficiency is a global nutritional disorder affecting majority of healthy people rather than those suffering from chronic diseases, affects about one third of people around the world and thereby causing clinical manifestations. This work represents new modality to increase the intestinal absorptivity and bioavailability of zinc from the diet by replacing traditional bulk form by zinc nanop...