Background and objectives: The aerial parts of Artemisia marschalliana Sprengel as an indigenous species of genus Artemisia in the East Azerbaijan province of Iran, was subjected to phytochemical analysis, as well asanti-proliferative, free-radical-scavenging and anti-malarialactivities. Methods: The chemical composition of the essential oil o...

1. Two important methods for the study of malarial pigment are described. (a) A method for obtaining a solution of malarial pigment from fixed tissues without the removal of a trace of hemoglobin from the red blood corpuscles. (b) A method for obtaining an iron reaction in malarial pigment. 2. By comparing the bleach reactions and solubility of melanins and malarial pigment, the dissimilarity o...

The role of hem&in in hemoglobin and bile pigment metabolism is not clearly defined. Opinion has been divided over the questions of whether or not hematin is a normal degradation product of hemoglobin and whether or not it is converted to bile pigment. Bingold observed that the occurrence of hen&in in the plasma is associated with a variety of pathologic conditions (1). The conditions in which ...

A mutant of Micrococcus pyogenes var. aureus isolated in 1952 has been used to investigate the biosynthesis of certain hematin enzymes. This strain has been described and its hemin requirements analysed in a series of papers (Jensen and Thofern 1953a, b, c, d; 1954). Since the present study is very closely related to and based upon the previous results, a brief summary is indicated: (1) The hem...

We have carried out a study of the reaction of 13Irydroperoxy-9-cis, 11-trans-octadecadienoic acid (linoleic acid hydroperoxide) with hematin. The major products are erythro-ll-hydroxy-l2,13-epoxy-S-octadecenoic acid, threo11-hydroxy12,13-epoxy-9-0~tadecenoic acid, 9,12,13-trihydroxy-lO-octadecenoic acid, 13-keto-9,ll-octadecadienoic acid, and 13-hydroxy-9,ll-octadecadienoic acid. Several minor...

Lead poisoning and acute intermittent porphyria (AIP) may exhibit similar neurologic manifestations, and they have in common elevated excretion of urinary aminolevulinic acid (ALA). Despite their similarities, the possible pathophysiologic connection between AIP and lead poisoning in not known. Because intravenous hematin administration has produced biochemical improvement in AIP, a hematin tri...

The phase II detoxification system glutathione transferase (GST) is associated with the establishment of parasitic nematode infections within the gastrointestinal environment of the mammalian host. We report the functional analysis of a GST from an important worldwide parasitic nematode of small ruminants, Haemonchus contortus. This GST shows limited activity with a range of classical GST subst...

Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from in vit...