Foundation NHS Trusts will be constituted in the same way as Mutual Societies, and local people and patients will be invited to become subscribers. Subscribers will elect a board of governors who will appoint the non-executive directors of the Trusts. Foundation Trusts will be outside the performance management system, but will be subject to a regulator and to inspection. Contracts with commiss...

To evaluate the expression of genes encoding cytokines, grow factors and cell cycle regulators in proliferative endometrium women with chronic endometritis (CE) compared to controls. We performed a case-control study on seven CE as diagnosed by hysteroscopy histology (Cases) six without (Controls). All underwent diagnostic plus endometrial biopsy during mid-proliferative phase menstrual cycle. ...

Abstract A proper balance of inflammatory cytokines at the fetal-maternal interface is crucial for successful embryo implantation and placental formation. Chemokine ligand 12 (CXCL12) receptor CXCR4 are expressed by fetal maternal tissues implicated in cytokine synthesis. However, mechanisms controlling axis profile not well characterized. Using an in-vivo sheep model, we previously demonstrate...

AIMS To examine the immune consequences of chronic alcoholism in man, in relation to the known association between alcoholism and raised incidence and severity of infections. METHODS In 36 alcoholics without liver disease, at the point of commencing withdrawal from alcohol, the following measures of immune competence were measured: the immunophenotypes of cells, acute phase proteins, the endo...

Background and aimAlthough studies have associated elevated prenatal obesity with increased risk of various diseases in offspring, little is known regarding the immune system. The aim this study was to evaluate relationship between levels cytokines umbilical cord blood development allergic disease during first 10 years life an offspring.MethodsA cohort term infants born at ShaoXing Women Childr...

This study demonstrates that passive transfer of Francisella tularensis-specific antibodies before experimental cutaneous infection with the live vaccine strain of F. tularensis has profound effects. Recipient mice showed stronger staining for TNF-alpha and IL12, and larger numbers of neutrophils in skin samples after infection than control mice.