A new modified Johnson-Cook model is developed to capture the non-linear thermal softening behaviour below austenite transformation temperature (723°C) in C45 ferritic-pearlitic steel, which not captured by original (JC) model. The physical mechanisms responsible for this are also studied. experimental quasi-static and high strain rate axisymmetric compression testing from 20°C 720°C implemente...

In this paper we suggest a number of statistical tests based on neural network models, that are designed to be powerful against structural breaks in otherwise stationary time series processes while allowing for a variety of nonlinear specifications for the dynamic model underlying them. It is clear that in the presence of nonlinearity standard tests of structural breaks for linear models may no...

Replicator dynamics and replication as used in evolutionary algorithms are, due to their most basic forms, structurally the same. This short note will prove this thesis. Although this finding is clear cut and easy to show, it is of great importance for the not yet united families of game theorists on the one hand and evolutionary programmers on the other, meaning that it is perfectly legal and ...

One of the most significant factors influencing the liquidity of the financial market is the amount of currency in circulation. Although the central bank is responsible for the distribution of the currency it cannot assess the demand for the currency, as that demand is influenced by the non-banking sector. Therefore, the amount of currency in circulation has to be forecasted. This paper introdu...

The Human Immunodeficiency Virus-1 integrase is responsible for the covalent insertion of a newly synthesized double-stranded viral DNA into the host cells, and is an emerging target for antivirus drug design. Raltegravir (RAL) and elvitegravir (EVG) are the first two integrase strand transfer inhibitors used in therapy. However, treated patients eventually develop detrimental resistance mutati...

Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stimuli t...

The Formation of Migrant Networks This paper provides the first direct evidence on the determinants of link formation among immigrants in the host society. We use a purposely-designed survey on a representative sample of Sri Lankan immigrants living in Milan to study how migrants form social links among them and the extent to which this network provides them with material support along three di...

We have synthesized the fluorine-I 8 labeled derivative of N-fert-butyl-aphenylnitrone (PBN), a free radical spin trapping agent widely used with electron spin resonance (ESR). N-tert-Butyl-a-(4-[18F]fluorophenyl)nitrone ([18F]FPBN) could be prepared with low radiochemical yield (3% decay corrected) by the direct aromatic nucleophilic substitution of N-tertbutyl-a-(4-nitrophenyl)nitrone with [1...