The replacement of amino acids 1 and 3 of glycopeptide antibiotics (dalbaheptides) with new amino acids or other chemical entities suitable to interact with both glycopeptide-resistant (D-Ala-D-Lactate) and susceptible (D-Ala-D-Ala) targets is one of the chemical strategies currently followed to pursue activity against highly glycopeptide-resistant VanA enterococci while maintaining activity ag...

The IMIRSEL (International Music Information Retrieval Systems Evaluation Laboratory) project provides an unprecedented platform for evaluating Music Information Retrieval (MIR) and Music Digital Library (MDL) techniques, by bringing together large corpora and significant computational resources with the necessary rights management and technical infrastructure to support a variety of MIR/MDL re...

In this paper we extend modal dependence logic MDL by allowing dependence atoms of the form dep(φ1, . . . , φn) where φi, 1 ≤ i ≤ n, are modal formulas (in MDL, only propositional variables are allowed in dependence atoms). The reasoning behind this extension is that it introduces a temporal component into modal dependence logic. E.g., it allows us to express that truth of propositions in some ...

Phorbol esters which activate protein kinase C (PKC) have been shown to enhance experimental lung metastasis. Therefore, it was reasoned that inhibitors of PKC might also modulate metastasis. We have investigated this possibility using a PKC inhibitor, MDL 27,032 [4-propyl-5(4-pyridinyl)-2(3H)-oxazolone], as well as staurosporine and H-7. Treatment of B16F1 murine melanoma cells with MDL 27,032...

Materials and methods We used two human MDL tissue samples, three human MDL cell lines (UW473, UW472 and DAOY), three human cerebellum tissue samples and two human cerebellum primary culture. The cell lines were characterized morphologically by light microscopy and immunophenotypically by flow cytometry. MDL cell lines and tissue samples, as well as, control cerebellum primary culture and tissu...

MDL 62,879 (GE2270 A) is a new peptide antibiotic that inhibits protein synthesis through an interaction with elongation factor Tu. MDL 62,879 was very active against gram-positive clinical isolates, particularly staphylococci and enterococci, for which MICs for 90% of isolates were < or = 0.13 micrograms/ml. It was equally active against isolates resistant to beta-lactams, erythromycin, gentam...

In this study, a odor concentration estimation model in the grow to finish swine pen was derived using principal component analysis and multiple regression models. 14 kinds of compounds were used. Prior statistical analysis, missing value (less than MDL)for each imputed with MDL/2, unit log-transformed follow normal distribution. The three components extracted through explained for 77.03% initi...

Abstract What role does knowledge play in expertise development professional domains, and to what extent that domain-specific interact with individuals’ strategic abilities their deep-seated interest a profession? These are central questions explored this chapter positions its within the framework of Model Domain Learning or MDL. The MDL is theoretical model used capture systematic changes know...