By William Caplan, MD Trina Histon, PhD Helen S Pettay, BA Weight Management and Obesity Initiative Strategic Model, Focus, and Goals As prevalence of overweight and obesity reached epidemic proportions, clinical intervention alone became obviously insufficient to address the problem. In January 2002, the Care Management Institute (CMI) of Kaiser Permanente (KP) launched the Weight Management a...

VPg unlinkase is an unusual eukaryotic enzyme that catalyzes hydrolysis of the phosphodiester bond between residues of the unique tyrosine of VPg (viral protein genome linked) and the 5' terminal uridylic acid of picornavirus RNA. Cellular targets of the VPg unlinking enzyme are yet unknown. To determine an essential nucleic part of the covalent linkage unit that is necessary for the VPg unlink...

TO THE EDITOR—Klebsiella pneumoniae carbapenemase (KPC)–producing K. pneumoniae (KPC-Kp) has reached a worldwide diffusion, and the associated mortality rate of infected patients is ranging from 45% to 56% [1]. Several risk factors for mortality were identified in patients with KPC-Kp bloodstream infection (KPC-Kp BSI), such as the severity of the underlying disease or the delay in administrati...

STUDY DESIGN Retrospective evaluation. PURPOSE To compare quality of life in postmenopausal women with osteoporotic vertebral fractures (OVFs) who underwent vertebroplasty (VP) or kyphoplasty (KP). OVERVIEW OF LITERATURE Patient with OVFs who do not respond to conservative treatment can be treated with VP or ballon KP for faster pain relief. There are controversies on which procedure is mor...

Serological analysis of recombinant tumor cDNA expression library (SEREX) is a powerful and widely used method to explore the cancer immune environment. In the present study, immunoscreening of normal testicular tissues and malignant mesothelioma (MM) cancer MSTO-211H cell line cDNA libraries with sera from 5 MM patients led to the isolation of 16 independent antigens, which were designated 'Ko...

We obtain the bi-Hamiltonian structure of the super KP hierarchy based on the even super KP operator Λ = θ + ∑∞ i=−2 Uiθ , as a supersymmetric extension of the ordinary KP bi-Hamiltonian structure. It is expected to give rise to a universal super W -algebra incorporating all known extended superconformal WN algebras by reduction. We also construct the super BKP hierarchy by imposing a set of an...

This work was carried out in collaboration between both authors. Author KP designed the study, wrote the protocol and supervised the work. Authors KP and ZG carried out all laboratories work and performed the statistical analysis. Author KP managed the analyses of the study. Author KP wrote the first draft of the manuscript. Author ZG managed the literature searches and edited the manuscript. B...

The partition coefficients (Kps) of six anti-inflammatory steroid drugs, dexamethasone (DMS), betamethasone (BMS), triamcinolone acetonide (TCLA), fluocinolone acetonide (FCLA), betamethasone 17,21-dipropionate (BMSDP), and clobetasole propionate (CBSP), for phosphatidylcholine (PC), and PC-cholesterol small unilamellar vesicles (SUVs) were determined by a second-derivative spectrophotometric m...

Degradation of the essential amino acid tryptophan along the kynurenine pathway (KP) yields several neuroactive intermediates, including the free radical generator 3-hydroxykynurenine, the excitotoxic N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid, and the NMDA and 7 nicotinic acetylcholine receptor antagonist kynurenic acid. The ambient levels of these compounds are determined by...