نتایج جستجو برای: دندریمر pamam
تعداد نتایج: 965 فیلتر نتایج به سال:
چکیده سابقه و هدف: کالاهای پنبه ای که در البسه و مصارف بیمارستانی بسیار مورد استفاده قرار می گیرند، همواره مستعد به حمله توسط عوامل بیماری زا و میکروبی هستند. با توجه به خصلت کاتیونیکی و با وجود گروه های آمین فراوان در نانوساختار دندریمر پلی پروپیلن ایمین، احتمالا این نانوساختار دارای خاصیت ضد میکروبی است. این تحقیق، به بررسی تاثیر نانو ساختار دندریمر پلی پروپیلن ایمین بر خاصیت ضد میکروبی پارچه...
Rheumatoid arthritis is a chronic autoimmune disease characterised by joint synovial inflammation, along with cartilage and bone tissue destruction. Dendrimers can offer new opportunities as drug delivery systems of molecules interest. Herein we aimed to develop poly(amidoamine) dendrimers (PAMAM), functionalised chondroitin sulphate (CS), lined anti-TNF α antibodies (Abs) provide anti-inflamma...
The immobilization of carbohydrates on gold surfaces is a prerequisite technology for carbohydrate-related studies, including those of carbohydrate-biomolecule interactions. Glycolipid domains in cell membranes, such as lipid rafts, are thought to play an important role in cell biology through their carbohydrate portions. To understand the recognition of glycolipid domains such as receptors for...
Phage display technology has been demonstrated to be a powerful tool for screening useful ligands that are capable of specifically binding to biomarkers on the surface of tumor cells. The ligands found by this technique, such as peptides, have been successfully applied in the fields of early cancer diagnostics and chemotherapy. In this study, a novel nonsmall cell lung cancer-targeting peptide ...
Interior tertiary amine groups of PAMAM-OH dendrimers (hydroxyl-terminated polyamidoamine, PAMAM) were modified by methylation to make these polymers have a more cationic character, which enabled electrostatic interaction between PAMAM-OH and plasmid DNA. A methylation reaction was dose-dependent, producing internally quaternized PAMAM-OH (QPAMAM-OH), thereby making tertiary amine/quaternary am...
BACKGROUND The advancement of gene silencing via RNA interference is limited by the lack of effective short interfering RNA (siRNA) delivery vectors. Rational design of polymeric carriers has been complicated by the fact that most chemical modifications affect multiple aspects of the delivery process. In this work, the extent of primary amine acetylation of generation 5 poly(amidoamine) (PAMAM)...
زمینه و هدف: هدف از پژوهش کنونی سنتز و بررسی اثرات ضد باکتریایی نانو دندریمر پلی آمیدوآمین-g7 در حذف باکتری های اشرشیاکلی، پروتئوس میرابیلیس، سالمونلا تیفی، باسیلوس سوبتیلیس و استافیلوکوکوس اورئوس در محیط آزمایشگاهی بود. روش بررسی: مطالعه به صورت تجربی در تیرماه 1394 در آزمایشگاه میکروبیولوژی دانشگاه علوم پزشکی ایران انجام گردید، اثر ضدباکتریایی نانو دندریمر پلی آمید و آمین-g7 به روش انتشار دیس...
Polyamidoamine dendrimers (PAMAM) represent a new class of hyperbranched, monodisperse, three-dimensional polymers with unique properties, which make them very promising carriers of antimicrobial agents. The present study aimed to evaluate the influence of PAMAM-NH₂ dendrimers generation two (G2) or three (G3) on physicochemical characteristics and structure of hydrogels with a model antibacter...
The immunotoxicity of three generations of polyamidoamine (PAMAM) dendrimers (G-4, G-5 and G-6) was evaluated in mouse macrophage cells in vitro. Using the Alamar blue and MTT assays, a generation dependent cytotoxicity of the PAMAM dendrimers was found whereby G-6 > G-5 > G-4. The toxic response of the PAMAM dendrimers correlated well with the number of surface primary amino groups, with incre...
In recent years, scientists have developed various biomaterials to remineralize human teeth to treat dentine hypersensitivity. Poly(amido amine) (PAMAM) dendrimers have become a research focus in this field. It has been demonstrated that PAMAM is able to create precipitates both on the surface of and within the dentinal tubules, however, there is little information about its effect on reducing ...
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