In recent years we have witnessed a blooming interest in innate lymphoid cell (ILC) biology thanks to the discovery of novel lineages of ILC that are phenotypically and functionally distinct from NK cells. While the importance of these novel ILC subsets as essential functional components of the early immune responses are now clearly established, many questions remain as to how early ILC develop...

PURPOSE The aims of this study were to compare the expression of sarcosine metabolism-related proteins between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) and to determine the implications of these results. MATERIALS AND METHODS Tissue microarrays were constructed, containing 30 samples from normal breast tissue, 114 samples from patients with ILC, and 692 samples fro...

In this paper, an iterative learning control method based on the recognition, response, and memory mechanism of immune system (IRRM-ILC) is proposed. According to the immunological recognition, response, and memory processes, several new components are designed and then combined with the conventional ILC. The proposed IRRM-ILC controller can mitigate the disturbances by detecting, identifying, ...

A simple iterative learning controller (ILC) is proposed for the tracking control of uncertain discrete-time non-linear systems performing the repetitive tasks. The tracking error of the current learning iteration is utilized in the ILC updating law. It is proven that, under relaxed conditions, the nal tracking error is bounded in the presence of uncertainty, disturbance and the ini-tialization...

ERBB2 and ERBB3 somatic gain-of-function mutations, which may be targeted by anti-ERBB2 therapies, were reported by high-throughput sequencing studies in 1% and 2% of invasive breast cancers respectively. Our study aims to determine ERBB2 and ERBB3 mutations frequencies in grade 3 and/or ERBB2-positive invasive lobular breast carcinomas (ILC). All the 529 ILC surgically-excised registered at In...

Microphthalmos is an ocular abnormality of the eye in which all tissues are significantly smaller than normal. It is subdivided into two categories as simple and complex microphthalmos. The complex type is associated with several ocular abnormalities (1). Posterior microphthalmos is another subtype of microphthalmos which is characterized by normal or near normal anterior segment dimensions, ye...

The study objectives were 1) to test the hypothesis that the lack of P-glycoprotein (P-gp) and the inhibition of breast cancer resistance protein (Bcrp) at the blood-brain barrier after cassette dosing of potent P-gp and Bcrp inhibitors were due to low plasma concentrations of those inhibitors and 2) to examine the effects of P-gp on the unbound brain (Cu,brain) and cerebrospinal fluid (CSF) co...

A P-type iterative learning controller (ILC) which includes a current iteration tracking error (CITE) in its high-order updating law is proposed for the tracking control of repetitive uncertain discrete-time non-linear systems. It is shown that, under relaxed conditions , the tracking error bounds are class-K functions of the bounds of uncertainty, disturbance and the ini-tialization error. The...

This paper presents an experimental validation of a recently proposed robust normoptimal iterative learning control (ILC). The robust ILC input is computed by minimizing the worst-case value of a performance index under model uncertainty, yielding a convex optimization problem. The proposed robust ILC design is experimentally validated on a lab scale overhead crane system, showing the advantage...