The regiocontrolled preparation of triarylisothiazoles is presented. 3-Halo-5-phenylisothiazole-4-carbonitriles, 1 (hal=Cl) and 18 (hal=I), are converted into the corresponding 4-bromo derivatives 5 (3-hal=Cl) and 24 (3-hal=I) via a Hunsdiecker strategy while the 4-iodo analogues 7 (3-hal=Cl) and 22 (3-hal=I) are prepared via a Hoffmann and Sandmeyer strategy. Regioselective Suzuki, Stille and ...

Nach dem kurzen Bericht ueber die Geschichte van Tetanus; haben wir in diesern Artikel ver­sucht,ueber die Epedirniologie, Pathophisiolo­gie,Aethiologie und die Frueh-und Spaet-Symp­ptome von dieser gcfahrlichen Krankheit,die einen Durchschnitt von 35% Mortalitaet hat,zu berichten.  In disern Artikel legen wir vi.ei wert,besoaders ueber die The·.rapie 1md der Prophyla.xe. Unc:I wii' hal)en bed...

Trials of novel compounds for the treatment of schizophrenia are typically tested in patients following brief withdrawal of ongoing medication despite known long-term changes in the dopamine (DA) system following chronic antipsychotic drug therapy. The present study explored the impact of withdrawal from repeated haloperidol (HAL) treatment, as well as the response to a novel α5 gamma-aminobuty...