Dry eye disease (DED) is a condition of the ocular surface characterized by tear film abnormalities and symptoms; inflammation principal pathogenesis. Recently, matrix metalloproteinase-9 (MMP-9) point-of-care immunoassay (InflammaDry) has become widely used as an ancillary diagnostic tool in routine clinical settings. This paper reviews role MMP-9 DED, relationships MMP-9-positivity on Inflamm...

background: oral lichen planus (olp) has been classified as a pre-malignant condition. matrix metalloproteinase-13 (mmp-13) or collagenase-3 may play a key role in cancer development. the aim of this study was to compare serum and saliva mmp-13 between patients with oral lichen planus (olp) and oral squamous cell carcinoma (oscc).   methods : this cross sectional study was performed on 30 patie...

background: spermatozoa cryopreservation is used for the management of infertility and some other medical conditions. the routinely applied cryopreservation technique depends on permeating cryoprotectants, whose toxic effects have raised the attention towards permeating cryoprotectants-free vitrification technique. objective: to compare between the application of slow cryopreservation and vitri...

background: mucous membrane pemphigoid (mmp) is considered an autoimmune blistering disease that  predominantly affects mucous membranes. various treatments are available for controlling the diseases, but not all of them may respond. objective: in this review, the data on seventy patients with mmp who were under treatment of intravenous immunoglobulin (ivig) are categorized and then analyzed. t...

There are emerging data on novel tumor markers such as matrix metalloproteinase-2 (MMP-2 or gelatinase-A), which play a key role in tissue invasion and metastasis. We designed an investigation to assess the usefulness of MMP-2 activity as compared to prostate specific antigen (PSA) in cancer staging process. We have analyzed the circulating form of MMP-2 in serum samples of patients suffering f...

Matrix Metalloproteinases (MMPs), these calcium-dependent zinc-containing endopeptidases play an important role in adipogenesis and angiogenesis by modifying tissues degrading the extracellular matrix (ECM). glycoproteins, gelatin, collagens, proteoglycans elastin are all found ECM. Current meta-analysis confirmed lower levels of IL-6 CRP was following bariatric surgery. Several studies have sh...

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), biomarkers calcification T1D patients SPK or kidn...

Matrix metalloproteases (MMPs) undergo post-translational modifications including pro-domain shedding. The activated forms of these enzymes are effective drug targets, but generating potent biological inhibitors against them remains challenging. We report the generation anti-MMP-7 inhibitory monoclonal antibody (GSM-192), using an alternating immunization strategy with active site mimicry antig...

  Background: Oral lichen planus (OLP) has been classified as a pre-malignant condition. Matrix metalloproteinase-13 (MMP-13) or collagenase-3 may play a key role in cancer development. The aim of this study was to compare serum and saliva MMP-13 between patients with oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).   Methods : This cross sectional study was performed on 30 pat...