نتایج جستجو برای: رژیم درمانی dhap
تعداد نتایج: 41279 فیلتر نتایج به سال:
The side chains of R269 and N270 interact with the phosphodianion of dihydroxyacetone phosphate (DHAP) bound to glycerol 3-phosphate dehydrogenase (GPDH). The R269A, N270A, and R269A/N270A mutations of GPDH result in 9.1, 5.6, and 11.5 kcal/mol destabilization, respectively, of the transition state for GPDH-catalyzed reduction of DHAP by the reduced form of nicotinamide adenine dinucleotide. Th...
The side chain cation of R269 lies at the surface of l-glycerol 3-phosphate dehydrogenase (GPDH) and forms an ion pair to the phosphodianion of substrate dihydroxyacetone phosphate (DHAP), which is buried at the nonpolar protein interior. The R269A mutation of GPDH results in a 110-fold increase in K(m) (2.8 kcal/mol effect) and a 41,000-fold decrease in k(cat) (6.3 kcal/mol effect), which corr...
Phosphatidic acid is synthesized by a particulate preparation of of guinea pig liver from dihydroxyacetone phosphate, acyl CoAs and NADPH via acyl dihydroxyacetone phosphate. Glycerol-3-phosphate is also converted to phosphatidate in this system. The phosphatidate formed via acyl dihydroxyacetone phosphate has more saturated fatty acid in the lposition than in the Z-position, while the fatty ac...
Phosphatidic acid is the biosynthetic precursor of all glycerolipids. To understand how phosphatidic acid biosynthesis is controlled in Saccharomyces cerevisiae, we studied the regulation of three enzyme activities involved in the synthesis of this glycerolipid precursor, i.e., glycerophosphate acyltransferase (GPAT), dihydroxyacetone phosphate acyltransferase (DHAPAT), and acyl DHAP reductase....
BACKGROUND Mass drug administration (MDA) using dihydroartemisinin plus piperaquine (DHAp) represents a potential strategy to clear Plasmodium falciparum infections and reduce the human parasite reservoir. METHODS A cluster-randomized controlled trial in Southern Province, Zambia, was used to assess the short-term impact of 2 rounds of community-wide MDA and household-level (focal) MDA with...
سابقه و هدف: درمان بروسلوز یک مشکل عمده پزشکی است و رژیم های متداول با طول مدت درمان شش هفته ای با عود زیاد همراه است. چون این بیماری در کشور ما شایع است، این مطالعه جهت مقایسه اثرات درمانی دو ماهه با دو رژیم درمانی متداول انجام شده است. مواد و روش ها: این مطالعه به روش کارآزمایی بالینی در بیماران مبتلا به بروسلوز از فروردین 1377 تا شهریور 1379 در بیمارستان یحیی نژاد بابل انجام شد. به بیماران ب...
سابقه و هدف: حمایت اجتماعی از عوامل مؤثر در پیروی از رژیم درمانی در بیماران مبتلا به پرفشاری خون می باشد. اما این ارتباط در جمعیت با پرفشاری خون هنوز به طور کامل بررسی نشده است. هدف از این پژوهش تعیین ارتباط بین حمایت اجتماعی با پیروی از رژیم درمانی در بیماران مبتلا به پرفشاری خون بود. مواد و روش ها: مطالعه حاضر، یک مطالعه مقطعی (توصیفی-تحلیلی) می باشد که در آن کلیه بیماران مبتلا به پرفشاری خو...
The peroxisomal acyl/alkyl dihydroxyacetone-phosphate reductase (EC 1.1.1.101) was solubilized and purified 5500-fold from guinea pig liver. The enzyme could be solubilized by detergents only at high ionic strengths in presence of the cosubstrate NADPH. Peroxisomes, isolated from liver by a Nycodenz step density gradient centrifugation, were first treated with 0.2% Triton X-100 to remove the so...
The formation of methylglyoxal from triose phosphates was studied in dialyzed whole cell homogenates of rat liver. In the cell-free system, methylglyoxal is largely derived from dihydroxyacetone phosphate (DHAP). The addition of the cofactor of glyoxalase activity, reduced glutathione (GSH), to the system inhibits the accumulation of methylglyoxal from DHAP, whereas the absence of GSH promo...
A factor (2-isocapryloyl-3R-hydroxymethyl-gamma-butyrolactone) is a representative of the gamma-butyrolactone autoregulators that trigger secondary metabolism and morphogenesis in the Gram-positive, filamentous bacterial genus Streptomyces. Here, we report the A factor biosynthesis pathway in Streptomyces griseus. The monomeric AfsA, containing a tandem repeat domain of approximately 80 aa, cat...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید