Enhanced rRNA synthesis is a downstream effect of many of the signaling pathways that are aberrantly activated in cancer, such as the PI3K/mTOR and MAP kinase pathways. Recently, two new rRNA synthesis inhibitors have demonstrated therapeutic effects on cancer cells while sparing normal cells. One of them, CX-5461, is currently in phase 1 clinical trials for hematological malignancies. Here, we...

In recent years several evidence demonstrated that some features of hippocampal biology, like neurogenesis, synaptic transmission, learning, and memory performances are deeply modulated by social, motor, and sensorial experiences. Fractalkine/CX(3)CL1 is a transmembrane chemokine abundantly expressed in the brain by neurons, where it modulates glutamatergic transmission and long-term plasticity...

OBJECTIVE Angiotensin-II (Ang-II) promotes the interaction of mononuclear cells with arterioles and neutrophils with postcapillary venules. To investigate the mechanisms underlying this dissimilar response, the involvement of fractalkine (CX(3)CL1) was explored. METHODS AND RESULTS Enhanced CX(3)CL1 expression was detected in both cremasteric arterioles and postcapillary venules 24 hours afte...

For every fixed set F ⊆ {0, 1}n the following problems are strongly polynomial time equivalent: given a feasible point x ∈ F and a linear objective function c ∈ ZZn, • find a feasible point x∗ ∈ F that maximizes cx (Optimization), • find a feasible point x ∈ F with cx > cx (Augmentation), and • find a feasible point x ∈ F with cx > cx such that x − x is “irreducible” (Irreducible Augmentation)....

Culex tritaeniorhynchus Giles and Cx. gelidus Theobald (Diptera: Culicidae), both vectors of Japanese encephalitis, were collected in 1984 and 1998 from two disease endemic localities in Sri Lanka: Anaradhapura and Kandy. Using wild-caught adult mosquitoes from light traps, log dosage-probit mortality curves for insecticide bioassays were obtained for three insecticides: malathion (organophosph...

The main vector of Brugia malayi in the small endemic focus on Hachijo-koshima Island was determined to be Ochlerotatus togoi (as Aedes togoi) [1]. As to Wuchereria bancrofti, many species of mosquitoes were experimentally examined for susceptibility in the laboratory as by Mochizuki in 1911 and 1913 [2, 3], Yamada in 1927 [4], Fujisaki in 1958 and 1959 [5, 6], and Omori in 1962 [7]. The result...

PURPOSE Our aim was to determine whether there is a correlation between cross-sectional areas of the left main coronary artery (LMCA), left anterior descending artery (LAD), and circumflex artery (CX) in normal cases using coronary CT angiography. METHOD Examinations of 180 patients (119 men and 61 women) were selected among 2248 consecutive coronary CT angiography studies. Cross-sectional ar...

A comparative study was conducted in rat primary cortical (CX) and mesencephalic (MC) neurons to investigate intracellular cascades activated during cyanide-induced injury and to determine the point at which the cascades diverge to produce either apoptosis or necrosis. Cyanide treatment (400 microM) for 24 h produced primarily apoptosis in CX cells, whereas the same concentration of cyanide ind...

AIM To investigate whether the changes of gap junction gene connexin messenger RNA in the noncancerous liver tissue of patients with hepatocellular carcinoma (HCC) could play a significant role in its postresection recurrence. METHODS Seventy-nine consecutive patients having undergone curative resection for HCC entered this study. Using a reverse-transcription polymerase chain reaction (RT-PC...