OBJECTIVES The aim of this research was to assess the efficacy of paclitaxel-eluting stents in chronic total coronary occlusions (CTO). BACKGROUND Percutaneous coronary interventions for CTOs are characterized by a high target vessel failure rate. METHODS In 48 consecutive patients, paclitaxel-eluting stents (Taxus, Boston Scientific Corp., Natick, Massachusetts) were implanted after succes...

A cladistic analysis of the medicinal plant Taxus, using the sequences of one chloroplast (trnS-trnQ spacer) and three nuclear taxadiene synthase (TS), 10-deacetylbaccatin III-10beta-O-acetyltransferase (DBAT), and 18S rDNA) molecular markers, was carried out by distance, parsimony, likelihood, and Bayesian methods. Three of the four New World species (T. brevifolia, T. floridana and T. globosa...

Phytosulfokine-alpha (PSK-alpha) is a small plant peptide (5 amino acids) that displays characteristics typically associated with animal peptide hormones. PSK-alpha was originally isolated based on its mitogenic activity with plant cultures; it has been reported to increase production of tropane alkaloids from Atropa belladonna, although its general influence on secondary metabolite production ...

In Canada, three subspecies of American badgers (Taxidea taxus (Schreber, 1777)) traditionally are identified; two of which are listed as endangered because of their restricted geographic range and low population sizes. To verify their subspecific designations and genetic insularity, we analyzed mitochondrial control region sequences within and among badger subspecies (Taxidea taxus jacksoni Sc...

CONTEXT Taxine-derived alkaloids, taxane-derived substances, and glycosides seem to be responsible for the toxicity of Taxus spp. by blocking microtubule, sodium and calcium channels causing conduction abnormalities. Cases with Taxus baccata acute intoxication have rarely been reported. CASE DETAILS We report the case of a 43-year-old man who ingested, for suicidal purposes, common (or Europe...

INTRODUCTION AND OBJECTIVES This article examines the cost impact associated with the utilization of the Taxus drug eluting stent versus a conventional bare-metal stent for percutaneous coronary interventions in a Spanish hospital setting. METHODS A decision analysis model has been developed to compare the intervention and re-hospitalization costs at 12 and 24 months post-intervention. The an...

Taxol® (generic name – Paclitaxel), the most promising chemotherapeuticagent was isolated from bark of different Taxus sp. As species arethreatened with extinction (endangered in Himalaya), thus it is imperativeto develop alternate and sustainable method for commercialization scaleup production paclitaxel. In this respect, physical chemical parametersare effective important key points active co...