نتایج جستجو برای: سلولهای 4t1

تعداد نتایج: 4357  

Journal: :Journal of Biomedicine and Biotechnology 2005
M. S. Brault R. A. Kurt

Monocyte chemoattractant protein-1 (MCP-1, CCL2) is produced by many different types of cells. In the current investigation, the effect of tumor-derived CCL2 on macrophages was evaluated to determine the extent to which this chemokine influenced the innate immune response to cancer. To do this, we used the 4T1 murine mammary carcinoma cell line that constitutively expresses CCL2 and generated 4...

2017
Kim Donati Christelle Sépult Natacha Rocks Silvia Blacher Catherine Gérard Agnès Noel Didier Cataldo

The premetastatic niche in distant organs prior to metastatic cell arrival emerged as an important step in the metastatic cascade. However, molecular mechanisms underlying this process are still poorly understood. In particular, whether neutrophil recruitment at a premetastatic stage promotes or inhibits metastatic cell seeding has to be clarified. We aimed at unraveling how neutrophil infiltra...

2011
Se-Jin Park Ran-Ju Kim Jeong-Seok Nam

The cancer stem cell (CSC) hypothesis proposes that CSCs are the root of cancer. CSC-targeted therapies may prevent cancer relapse and provide more effective treatment. The expression of aldehyde dehydrogenase 1, as assessed by the Aldefluor assay, has been recognized as a marker of CSCs in breast cancer. Inhibitors of DNA-binding proteins (IDs) have an important role in stem cell differentiati...

2012
Hyun Sook Lee Ae Wha Ha Woo Kyoung Kim

We investigated the effects of resveratrol on metastasis in in vitro and in vivo systems. 4T1 cells were cultured in the presence of various concentrations (0-30 µmol/L) of resveratrol. For experimental metastasis, BALB/c mice were injected intravenously with 4T1 cells in the tail vein, and were orally administered various concentrations (0, 100, or 200 mg/kg Body weight) of resveratrol for 21 ...

2011
Inna Serganova Asif Rizwan Xiaohui Ni Sunitha B. Thakur Jelena Vider James Russell Jason A. Koutcher

Purpose: We compared the metabolic profiles and the association between LDH-A expression and lactate production in two isogenic murine breast cancer cell lines and tumors (67NR and 4T1). These cell lines were derived from a single mammary tumor and have different growth and metabolic phenotypes. Experimental Design: LDH-A expression, lactate concentration, glucose utilization, and oxygen consum...

Journal: :International journal of oncology 2014
Kazunori Hamamura Kazumasa Minami Nancy Tanjung Qiaoqiao Wan Masahiko Koizumi Nariaki Matsuura Sungsoo Na Hiroki Yokota

Blocking dephosphorylation of eukaryotic translation initiation factor 2α (eIF2α) is reported to alter proliferation and differentiation of various cells. Using salubrinal and guanabenz as an inhibitory agent of dephosphorylation of eIF2α, we addressed a question whether an elevated level of phosphorylated eIF2α attenuates malignant phenotypes of triple negative breast cancer cells (TNBCs) that...

2013
Shengmei Feng Guochun Zhu Matthew McConnell Lianfu Deng Qiang Zhao Mengrui Wu Qi Zhou Jinshen Wang Jin Qi Yi-Ping Li Wei Chen

Previous studies have shown that Atp6v1c1, a regulator of the assembly of the V0 and V1 domains of the V-ATPase complex, is up-regulated in metastatic oral tumors. Despite these studies, the function of Atp6v1c1 in tumor growth and metastasis is still unknown. Atp6v1c1's expression in metastatic oral squamous cell carcinoma indicates that Atp6v1c1 has an important function in cancer growth and ...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011
Angela M Boutté David B Friedman Matthew Bogyo Yongfen Min Li Yang P Charles Lin

Myeloid-derived suppressor cells (MDSCs) are significantly increased in cancer patients and tumor bearing-animals. MDSCs infiltrate into tumors and promote tumor invasion and metastasis. To identify the mediator responsible for the prometastatic property of MDSCs, we used proteomics. We found neutrophilic granule protein (NGP) was decreased >2-fold in MDSCs from metastatic 4T1 tumor-bearing mic...

2012
Rachel F. Cox Allan Jenkinson Kerstin Pohl Fergal J. O’Brien Maria P. Morgan

Bone is the most common site of metastasis for breast cancer, however the reasons for this remain unclear. We hypothesise that under certain conditions mammary cells possess osteomimetic capabilities that may allow them to adapt to, and flourish within, the bone microenvironment. Mammary cells are known to calcify within breast tissue and we have recently reported a novel in vitro model of mamm...

2015
Hatem Soliman Melanie Mediavilla-Varela Scott J Antonia

BACKGROUND There is increasing interest in using cancer vaccines to treat breast cancer patients in the adjuvant setting to prevent recurrence in high risk situations or in combination with other immunomodulators in the advanced setting. Current peptide vaccines are limited by immunologic compatibility issues, and engineered autologous cellular vaccines are difficult to produce on a large scale...

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