Supplementary data ml http://rspb.royalsocietypublishing.org/content/suppl/2009/02/12/272.1581.2627.DC1.ht "Data Supplement" References http://rspb.royalsocietypublishing.org/content/272/1581/2627.full.html#related-urls Article cited in: http://rspb.royalsocietypublishing.org/content/272/1581/2627.full.html#ref-list-1 This article cites 51 articles, 4 of which can be accessed free Email alertin...

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PURPOSE Neratinib is an orally administered, small-molecule, irreversible pan-ErbB inhibitor in development for the treatment of ErbB2-positive breast cancer. This study assessed the effects of therapeutic and supratherapeutic neratinib concentrations on cardiac repolarization, in accordance with current regulatory guidance. EXPERIMENTAL DESIGN This was a two-part study in healthy subjects. I...

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In this study, the changes in UV absorbance of water samples were characterized using defined differential UV spectroscopy (DUV), a novel spectroscopic technique. Chlorination experiments were conducted with water samples from Terkos Lake (TL) and Büyükçekmece Lake (BL) (Istanbul, Turkey). The maximum loss of UV absorbance for chlorinated TL and BL raw water samples was observed at a wavelength...

AIM To describe the outcomes of low-birth-weight babies using an 'early discharge' Kangaroo care policy and to identify barriers to their follow-up. METHODS Prospective descriptive study of all 272 babies admitted to a Kangaroo Care Ward in Malawi from November 2003 to May 2004. Infants were discharged to outpatient care once weighing over 1300 g and gaining weight. Follow-up was carried out ...

This memo presents the case for adding smaller antennas to the ALMA array. Smaller, higher precision antennas are better able to exploit the excellent submillimeter potential of the 5000 m altitude site, and are better matched to the angular size of many submillimeter sources. Model studies show that the image delity of mosaiced observations with the ALMA array will be limited by pointing and s...

PURPOSE Wild-type sequence (wt) p53 peptides are attractive candidates for broadly applicable cancer vaccines, currently considered primarily for patients whose tumors overexpress p53. Circumstances exist, however, where increased p53 degradation may result in appreciable presentation of p53-derived peptides, despite low p53 expression. Squamous cell carcinoma of the head and neck is associated...

INTRODUCTION The aim of this study was to construct a lentivirus vector with survivin promoter (pSur)-driven apoptin and test its efficiency in suppressing the growth of tumor cells. MATERIAL AND METHODS Expression cassettes with different fragments of survivin gene promoter (pSur, 161 bp, 272 bp, 990 bp) driving 6XHis-tagged apoptin were constructed to generate recombinant lentivirus, of whi...

The fate of radiotocopherol was studied in plasma and tissues of sheep at various intervals after injection of single intravenous doses of 3H-labelled D-alpha-tocopherol. Plasma samples were taken at regular intervals after dosing and selected tissues were taken from all sheep after slaughter and assayed for radioactivity and D-alpha-tocopherol. Sheep were killed in groups of five at 24, 72, 96...