OBJECTIVE To assess independent prognostic factors described in the literature. Thus, to identify different risk groups. METHODS Review of the records with a diagnosis of primary vulvar squamous cell carcinoma (January/1992-January/2012). INCLUSION CRITERIA depth of stromal invasion (DSI) >1mm, pathological tumor size >2 cm, and pathological tumor-free margin ≥ 8 mm. Patients who underwent ...

BACKGROUND & AIMS We previously demonstrated that short-term oral administration of the probiotic Lactobacillus reuteri 6475 enhanced bone density in male but not female mice. We also established that L. reuteri 6475 enhanced bone health and prevented bone loss in estrogen-deficient female mice. In this study, we tested whether a mild inflammatory state and/or a long-term treatment with the pro...

In layer 2/3 of neocortex, brief trains of action potentials in pyramidal neurons (PNs) induce the mobilization of endogenous cannabinoids (eCBs), resulting in a depression of GABA release from the terminals of inhibitory interneurons (INs). This depolarization-induced suppression of inhibition (DSI) is mediated by activation of the type 1 cannabinoid receptor (CB1) on presynaptic terminals of ...

We introduce a procedure, called the Degree Sequence Index Strategy (DSI), by which to bound graph invariants by certain indices in the ordered degree sequence. As an illustration of the DSI strategy, we show how it can be used to give new upper and lower bounds on the k-independence and the k-domination numbers. These include, among other things, a double generalization of the annihilation num...

Despite the importance of Bowen theory (M.Bowen, 1976,1978; M. E. Kerr&Bowen, 1988) in the field of family therapy, there have been relatively few studies to date examining its constructs or propositions. To fill this gap, a self-report instrument, the Differentiation of Self Inventory (DSI) has been developed. The DSI is a multidimensional measure of differentiation that focuses specifically o...

Histological studies have shown that the myocardium consists of an array of crossing helical fiber tracts. Changes in myocardial fiber architecture occur in ischemic heart disease and heart failure, and can be imaged non-destructively with diffusion-encoded MR. Several diffusion-encoding schemes have been developed, ranging from scalar measurements of mean diffusivity to a 6-dimensional imaging...

[1] We analyzed dSi of dissolved silicate for eight water column profiles across the Southern Ocean (south of Australia in spring 2001) from the Seasonal Ice Zone (SIZ) north to the Subantarctic Zone (SAZ), including the first isotopic compositions measured for Si-depleted seawaters. All profiles display mixed layer enrichments in heavy Si isotopes relative to deep water in accordance with pref...

OBJECTIVE to validate the dynamic spectral imaging (DSI) colposcope's colour-coded map in discriminating high- from low-grade cervical lesions and non-neoplastic tissue. DESIGN prospective, comparative, multicentre clinical trial. SETTING the colposcopy clinics of three Dutch hospitals. POPULATION women of 18 years or over with an intact cervix, referred for colposcopy. METHODS during a...

BACKGROUND The cerebellum is a complex structure that can be affected by several congenital and acquired diseases leading to alteration of its function and neuronal circuits. Identifying the structural bases of cerebellar neuronal networks in humans in vivo may provide biomarkers for diagnosis and management of cerebellar diseases. OBJECTIVES To define the anatomy of intrinsic and extrinsic c...

We compared self-reported handicap (Hearing Handicap Inventory for the Elderly, HHIE) scores before and after a 6-week period of hearing aid use in subjects drawn from a pool of 115 elderly persons with hearing impairment. Study patients (PTs) were divided into two categories according to whether scores on a dichotic listening test (Dichotic Sentence Identification Test, DSI) were normal or abn...