Abstract Background Major depressive disorder (MDD) is a common psychiatric that affects nearly 11.1-14.6 % of the population in their lifetime. Pathophysiology and brain imaging findings show degenerative inflammatory processes may play role. Meta-analysis voxel-based morphometry studies MDD demonstrated significant gray matter loss. From anatomical embryological perspectives, retina can be co...

Purpose. To evaluate the change in functional activity of retinal ganglion cells (RGCs) response to intraocular pressure (IOP) drop patients with newly diagnosed early stage primary open-angle glaucoma (POAG) using a pattern electroretinogram (PERG). Material and methods . A prospective non-randomized cohort study included 12 (24 eyes) including 5 men, 7 women, aged 63.42 ± 2.96 years POAG at l...

BACKGROUND Recently, we reported a reduced retinal contrast gain in unmedicated and medicated patients with major depression. AIMS To analyse whether the contrast gain normalises after successful antidepressive therapy by recording the pattern electroretinogram (PERG) in healthy controls and patients with depression before and after antidepressive therapy. METHOD Fourteen patients diagnosed...

Both acquired color vision deficiencies and abnormal pattern electroretinograms (PERGs) are observed in patients with ocular hypertension (OHT) as well as in patients with glaucoma. In the present study we determined the prevalence of both of these functional deficits in a large group of OHT patients (N = 130). Color vision was tested with the desaturated D-15 and a color confusion score was us...

PURPOSE To evaluate macular function and neural conduction along postretinal visual pathways in amblyopic patients. METHODS Twenty-five anisometropic amblyopic patients (mean age, 7 ± 1.9 years; visual acuity [VA]: 0.44 ± 0.27 logMAR in amblyopic [AM] eyes and 0.023 ± 0.067 logMAR in sound [SE] eyes) and 25 age-similar control subject ([CE] eyes, VA of 0.0 ± 0.0 logMAR in both eyes) were enro...

PURPOSE The purpose of this study was to compare psychophysical and electrophysiological testings in early optic nerve dysfunction in a group of clinically asymptomatic subjects with suspect ocular hypertension (OHT). METHODS Forty eyes of 40 patients with suspect OHT and asymmetrical horizontal cup/disc ratio (0.2/0.4), 22 eyes of 22 patients with open-angle glaucoma (OAG), and 40 eyes of 40...