-Particles of the small filamentous coliphage M13 contain not only the major coat protein, which is the product of phage gene 8, but also a minor coat protein, the A protein, which is the product of gene 3. The A protein has a molecular weight of approximately 70,000 daltons, is present in one copy per virion, and is responsible for phage attachment to host cells. Also associated with purified ...

BACKGROUND After implementation of routine infant MenC vaccination, MenB remains a serious cause of meningococcal disease, yet to be targeted by vaccination programs in several countries. This study (NCT01339923) investigated the immunogenicity and safety of MenC CRM-conjugated vaccine (MenC-CRM) concomitantly administered with MenB vaccine (4CMenB). METHODS Infants (N=251) were randomised 1:...

KELL is a member of the M13 family of type II neutral endopeptidases, which functions as a blood group antigen in human and animal populations. KELL amino acid sequences and structures and KEL gene locations were examined using bioinformatic data from several mammalian genome projects. Mammalian KELL sequences shared 55-99% identity, as compared with 21-31% sequence identities with other M13-li...

We report on 40 kiloseconds of ROSAT HRI observations of the globular cluster M92 (NGC 6341) and 20 kiloseconds of observations of the globular cluster M13 (NGC 6205). We find that the low-luminosity (10 erg sec at 7.5 kpc) source previously observed near the core of M92 with the ROSAT PSPC remains unresolved at HRI resolution; we can identify it with M92 with 99 per cent confidence. In M13 we ...

Draga Pihler-Puzović1,†, Anne Juel1, Gunnar G. Peng2, John R. Lister2 and Matthias Heil3 1Manchester Centre for Nonlinear Dynamics and School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK 2Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK 3School of Mathematics and Manchester Cent...

E. E. Champion, S. J. Mann, J. D. Glazier, C. J. P. Jones, J. M. Rawlings, C. P. Sibley, and S. L. Greenwood Academic Unit of Child Health, University of Manchester, St. Mary’s Hospital, Manchester, M13 OJH; Waltham Centre for Pet Nutrition, Waltham on the Wolds, Melton Mowbray, Leicestershire, LE14 4RT; and Academic Unit of Obstetrics and Gynaecology, University of Manchester, St. Mary’s Hospi...

We study a construction of the Mathieu group M12 using a game reminiscent of Loyd’s “15-puzzle”. The elements of M12 are realized as permutations on 12 of the 13 points of the finite projective plane of order 3. There is a natural extension to a “pseudogroup” M13 acting on all 13 points, which exhibits a limited form of sextuple transitivity. Another corollary of the construction is a metric, a...

Beta-lactam resistance in mycobacteria results from an interplay between the following: (i) beta-lactamase production, (ii) affinity of the penicillin-binding proteins (PBPs) for the drugs, and (iii) permeation of the drugs. A laboratory mutant of Mycobacterium smegmatis was studied in order to evaluate the roles of these factors in beta-lactam resistance. Mutant M13 was between 7- and 78-fold ...

Gunnar G. Peng1,†, Draga Pihler-Puzović2, Anne Juel2, Matthias Heil3 and John R. Lister1 1Department of Applied Mathematics and Theoretical Physics, University of Cambridge, Wilberforce Road, Cambridge CB3 0WA, UK 2Manchester Centre for Nonlinear Dynamics and School of Physics and Astronomy, University of Manchester, Oxford Road, Manchester M13 9PL, UK 3School of Mathematics and Manchester Cent...