BRAF oncogenic mutations have been identified in significant numbers of melanocytic lesions. To correlate BRAF mutation and melanoma progression, we screened BRAF mutations in 65 melanocytic lesions, including nevi, radial growth phase (RGP), vertical growth phase (VGP) melanomas, and melanoma metastases, as well as 25 melanoma cell lines. PCR and direct sequencing were used to analyze DNA samp...

PURPOSE The purpose of the study was to evaluate the presentation and management of posthysterectomy ureteral injuries. PATIENTS AND METHODS Fourteen patients with ureteric injuries after hysterectomy for benign diseases were evaluated. The diagnosis was done based on clinical presentation, intravenous urogram, computed tomography, cystoscopy, and retrograde pyelogram (RGP) depending on the c...

Background. Congenital midureteric stricture (MUS) is a rare malformation. We report our experience with five cases seen over a period of 4 years from 2010 to 2014. Materials and Methods. The study was based on the retrospective analysis of five patients diagnosed as having MUS. Diagnosis was suspected after fetal ultrasonography (USG) in one patient and magnetic resonance urography (MRU) in fo...

The Rayon grade pulp (RGP) drain effluent of pulp and paper mill was studied to find out pollutant loading and its control measures by low cost and efficient treatment method. Upflow anaerobic fixed packed bed reactor (UAFPBR) with brick ballasts as packing material was used for this purpose. This was compared with conventional anaerobic treatment method. The digested slurry was taken as inocul...

We generalize the characterizations of the positive core and the positive prekernel to TU games with precedence constraints and show that the positive core is characterized by non-emptiness (NE), boundedness (BOUND), covariance under strategic equivalence, closedness (CLOS), the reduced game property (RGP), the reconfirmation property (RCP) for suitably generalized Davis-Maschler reduced games,...

Cersosimo, Eugenio, Irina N. Zaitseva, and Mohamed Ajmal. Effects of b-adrenergic blockade on hepatic and renal glucose production during hypoglycemia in conscious dogs. Am. J. Physiol. 275 (Endocrinol. Metab. 38): E792–E797, 1998.—To investigate the role of b-adrenergic mechanisms in the counterregulatory response of the liver and kidney to hypoglycemia, we studied 10 dogs before and after a 2...

PURPOSE Hypoxia impairs the barrier function of the corneal epithelium. This function depends on tight junctions, of which zonula occludens (ZO)-1 is a major component. The authors have investigated the effects of hypoxia on ZO-1 localization and expression in the rabbit corneal epithelium in vivo. METHODS A polymethylmethacrylate (PMMA) or rigid gas-permeable (RGP) lens was applied to one ey...

BACKGROUND This study aimed to evaluate anterior segment spectral optical coherence tomography (AS SOCT) for assessing the lens-to-cornea fit of rigid gas-permeable (RGP) lenses. The results were verified with the fluorescein pattern method, considered the criterion standard for RGP lens alignment evaluations. MATERIAL AND METHODS Twenty-six eyes of 14 patients were enrolled in the study. Ini...

OBJECTIVE Periodontitis, an infectious disease caused by periodontopathic bacteria, including Porphyromonas gingivalis, is reported to be accelerated by stress, under which noradrenaline levels are increased in the bloodstream. The purpose of this study was to evaluate the effects of noradrenaline on P. gingivalis. DESIGN P. gingivalis was incubated in the presence of 25μM, 50μM, or 100μM adr...

Sixteen monoclonal antibodies that were obtained after immunization of BALB/c mice with intact melanoma cells or extracts of melanoma cells were tested for reactivity with normal and malignant melanocytic cells in situ, using an immunoperoxidase technique on frozen tissue sections. Sections representing six histopathologically defined stages of tumor progression, ranging from normal melanocytes...